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Rat Anti-NTN1 Recombinant Antibody (4D56) (CBMAB-N3751-WJ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
4D56
Antibody Isotype
IgG2
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
netrin 1
Introduction
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
Entrez Gene ID
18208
UniProt ID
O09118
Alternative Names
Netrin 1; Epididymis Tissue Protein Li 131P; Netrin-1; NTN1L; Netrin 1, Mouse, Homolog Of;
Function
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977).
Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977).
It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis (PubMed:15343335).
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Anterior/posterior axon guidanceIEA:Ensembl
Apoptotic processIEA:UniProtKB-KW
Cdc42 protein signal transductionISS:UniProtKB
Cell-cell adhesionIEA:Ensembl
Chemorepulsion of axonISS:UniProtKB
Dendrite developmentManual Assertion Based On ExperimentIBA:GO_Central
Inner ear morphogenesisIEA:Ensembl
Mammary gland duct morphogenesisIEA:Ensembl
Motor neuron axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of axon extensionIEA:Ensembl
Neuron migrationIEA:Ensembl
Nuclear migrationIEA:Ensembl
Positive regulation of axon extensionISS:UniProtKB
Positive regulation of cell motilityISS:UniProtKB
Positive regulation of cell population proliferationIEA:Ensembl
Ras protein signal transductionISS:UniProtKB
Regulation of cell migrationIEA:Ensembl
Regulation of synapse assemblyIEA:Ensembl
Substrate-dependent cell migration, cell extensionISS:UniProtKB
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Cytoplasm
Mainly secreted.
Involvement in disease
Mirror movements 4 (MRMV4):
A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. MRMV4 inheritance is autosomal dominant.
More Infomation

Zhang, Y., Lan, J., Zhao, D., Ruan, C., Zhou, J., Tan, H., & Bao, Y. (2023). Netrin‐1 upregulates GPX4 and prevents ferroptosis after traumatic brain injury via the UNC5B/Nrf2 signaling pathway. CNS neuroscience & therapeutics, 29(1), 216-227.

Cline, M. M., Juarez, B., Hunker, A., Regiarto, E. G., Hariadi, B., Soden, M. E., & Zweifel, L. S. (2023). Netrin-1 regulates the balance of synaptic glutamate signaling in the adult ventral tegmental area. Elife, 12, e83760.

Mentxaka, A., Gómez-Ambrosi, J., Neira, G., Ramírez, B., Becerril, S., Rodríguez, A., ... & Frühbeck, G. (2023). Increased expression levels of netrin-1 in visceral adipose tissue during obesity favour colon cancer cell migration. Cancers, 15(4), 1038.

Barnault, R., Verzeroli, C., Fournier, C., Michelet, M., Redavid, A. R., Chicherova, I., ... & Parent, R. (2022). Hepatic inflammation elicits production of proinflammatory netrin‐1 through exclusive activation of translation. Hepatology, 76(5), 1345-1359.

Nakayama, H., Ohnuki, H., Nakahara, M., Nishida-Fukuda, H., Sakaue, T., Fukuda, S., ... & Kusumoto, C. (2022). Inactivation of axon guidance molecule netrin-1 in human colorectal cancer by an epigenetic mechanism. Biochemical and biophysical research communications, 611, 146-150.

Mentxaka, A., Gómez-Ambrosi, J., Ramírez, B., Rodríguez, A., Becerril, S., Neira, G., ... & Catalán, V. (2022). Netrin-1 promotes visceral adipose tissue inflammation in obesity and is associated with insulin resistance. Nutrients, 14(20), 4372.

Schlegel, M., Sharma, M., Brown, E. J., Newman, A. A., Cyr, Y., Afonso, M. S., ... & Moore, K. J. (2021). Silencing myeloid netrin-1 induces inflammation resolution and plaque regression. Circulation research, 129(5), 530-546.

Abdullah, A., Herdenberg, C., & Hedman, H. (2021). Netrin-1 functions as a suppressor of bone morphogenetic protein (BMP) signaling. Scientific reports, 11(1), 8585.

Sharma, M., Schlegel, M., Brown, E. J., Sansbury, B. E., Weinstock, A., Afonso, M. S., ... & Moore, K. J. (2019). Netrin-1 alters adipose tissue macrophage fate and function in obesity. Immunometabolism, 1(2), e190010.

Yin, K., Wang, L., Xia, Y., Dang, S., Zhang, X., He, Z., ... & Xu, Z. (2019). Netrin-1 promotes cell neural invasion in gastric cancer via its receptor neogenin. Journal of Cancer, 10(14), 3197.

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For research use only. Not intended for any clinical use.

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