Respiratory Syncytial Virus (RSV) Nucleoprotein

Respiratory Syncytial Virus (RSV) Nucleoprotein

Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases (PubMed:23677789, PubMed:19965480, PubMed:31229488).
RNA replication depends on the availability of soluble nucleoprotein (PubMed:9299631, PubMed:22623798).
The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication (PubMed:22623798).
Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway (PubMed:32878896).
May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs (PubMed:22623778).

Biological Process suppression by virus of host NF-kappaB cascadeIEA:UniProtKB-KW
Biological Process suppression by virus of host PKR signalingIEA:UniProtKB-KW
Biological Process suppression by virus of host type I interferon-mediated signaling pathwayIEA:UniProtKB-KW
Biological Process suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activityIEA:UniProtKB-KW
Biological Process suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activityIEA:UniProtKB-KW

Virion
Host cytoplasm
Localizes in cytoplasmic inclusion bodies.

Tyrosine phosphorylation modulates viral transcription and replication.