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Recombinant Mouse Anti-Respiratory Syncytial Virus (RSV) Nucleoprotein Antibody (V2-624524) (CBMAB-MD296-LY)

The product is antibody recognizes RSV. The antibody CB023 immunoassay techniques such as: ELISA, IHC(f).
See all Respiratory Syncytial Virus (RSV) Nucleoprotein antibodies

Summary

Host Animal
Mouse
Specificity
RSV
Clone
V2-624524
Antibody Isotype
IgG1
Application
ELISA, IHC(f)

Basic Information

Immunogen
Bovine RSV (Strains 127, SNK and 9007). Human RSV Strains A2, Long, Randall and 8/60.
Specificity
RSV
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.5
Preservative
0.09% Sodium Azide
Purity
> 95% Purity determined by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Respiratory Syncytial Virus (RSV) Nucleoprotein
Function
Encapsidates the viral RNA genome by forming a left-handed helical nucleocapsid that protects the RNA from nucleases (PubMed:23677789, PubMed:19965480, PubMed:31229488).
RNA replication depends on the availability of soluble nucleoprotein (PubMed:9299631, PubMed:22623798).
The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication (PubMed:22623798).
Together with the phosphoprotein, sequesters host NF-kappa-B in inclusion bodies (IBs) thereby inhibiting this host defense pathway (PubMed:32878896).
May also act as a modulator of the innate immune response by sequestration of host IFIH1/MDA5 and MAVS into IBs (PubMed:22623778).
Biological Process
Biological Process suppression by virus of host NF-kappaB cascadeIEA:UniProtKB-KW
Biological Process suppression by virus of host PKR signalingIEA:UniProtKB-KW
Biological Process suppression by virus of host type I interferon-mediated signaling pathwayIEA:UniProtKB-KW
Biological Process suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activityIEA:UniProtKB-KW
Biological Process suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activityIEA:UniProtKB-KW
Cellular Location
Virion
Host cytoplasm
Localizes in cytoplasmic inclusion bodies.
PTM
Tyrosine phosphorylation modulates viral transcription and replication.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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