RIOK3

This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

Full Name

RIO Kinase 3

Function

Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708).
Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883).
Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502).
May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).

Biological Process

Biological Process cellular response to dsDNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to dsRNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process chromosome segregationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process defense response to virusIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process maturation of SSU-rRNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of MDA-5 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of interferon-beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein phosphorylationIEA:InterPro

Cellular Location

Cytoplasm

PTM

Autophosphorylated (in vitro).