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Mouse Anti-RIOK3 Recombinant Antibody (CBCNR-517) (CBMAB-R2702-CN)

This product is a Mouse antibody that recognizes RIOK3. The antibody CBCNR-517 can be used for immunoassay techniques such as: WB.
See all RIOK3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-517
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
RIO Kinase 3
Introduction
This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Entrez Gene ID
8780
UniProt ID
O14730
Alternative Names
RIO Kinase 3; SudD (Suppressor Of BimD6, Aspergillus Nidulans) Homolog; SudD Homolog; SUDD; Homolog Of The Aspergillus Nidulans SudD Gene Product; SudD Suppressor Of Aspergillus Nidulans BimD6 Homolog;
Function
Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708).
Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883).
Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502).
May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).
Biological Process
Biological Process cellular response to dsDNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to dsRNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process chromosome segregationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process defense response to virusIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process maturation of SSU-rRNAManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of MDA-5 signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of innate immune responseManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of interferon-beta productionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein phosphorylationIEA:InterPro
Cellular Location
Cytoplasm
PTM
Autophosphorylated (in vitro).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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