RPL10L

This gene encodes a protein sharing sequence similarity with ribosomal protein L10. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. This gene is intronless. [provided by RefSeq]

Full Name

ribosomal protein L10-like

Function

Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (By similarity).
Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis (PubMed:12490704).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:32669547).
The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (PubMed:23636399, PubMed:25901680, PubMed:32669547).
The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (PubMed:23636399, PubMed:25901680, PubMed:32669547).
The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25901680, PubMed:32669547).

Biological Process

Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process male meiosis IISS:UniProtKB
Biological Process ribosomal large subunit assemblyISS:UniProtKB
Biological Process spermatogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translationIEA:InterPro

Cellular Location

Cytoplasm

Involvement in disease

Spermatogenic failure 63 (SPGF63):
An autosomal recessive male infertility disorder characterized by severe oligozoospermia and reduced progressive sperm motility.