The protein SCEL (Sciellin) exists mainly in epithelial cells and specific stem cells. The protein functions to maintain structural integrity and functional characteristics of these cells. The protein SCEL participates in cell adhesion and signaling mechanisms which enable cells to interact with their environment. SCEL functions in stem cells to maintain stem cell properties while controlling immune responses which helps maintain tissue homeostasis and repair functions. The first discovery of SCEL occurred during research on epithelial cell structures before scientists extensively studied its cellular functions. The unique structural elements of SCEL including multiple domains and transmembrane regions have enabled scientists to study protein-protein interactions and cellular signaling pathways which improved their understanding of cellular biology and tissue development.
The molecular weight of Sciellin (SCEL) is approximately 120 kDa for this protein. The molecular weight of SCEL shows minor variations between species due to differences in amino acid sequences and post-translational modifications.
| Species | Human | Mouse | Rat |
| Molecular Weight (kDa) | 120 | 118 | 122 |
| Primary Structural Differences | Contains multiple domains, including LIM domains, which are crucial for protein interactions and functions. | Slightly lower molecular weight compared to human SCEL, with minor variations in amino acid sequences that may affect protein stability and interactions. | Slightly higher molecular weight due to additional post-translational modifications that can influence protein function and localization. |
The protein SCEL (Sciellin) contains 265 amino acids which organize into complex structural patterns through its alpha-helices and beta-sheets primary structure. The SCEL protein structure contains multiple domains with an Ig-like domain that enables cell adhesion and signaling functions. The Ig-like domain functions as a critical component for cell-cell interactions which helps preserve tissue structure. The secondary structure of SCEL consists of alpha-helices and beta-sheets that create transmembrane segments and extracellular portions. The cytoplasmic tail of the protein functions to control signaling pathways that occur inside cells. The protein structure of SCEL depends on its transmembrane regions and Ig-like domain to perform cell adhesion and signaling functions.
Key structural properties of SCEL:
SCELs main role is to uphold the stability and essential traits of cells and stem cells while also participating in bodily functions, like cell attachment, control of immune responses and the mending of tissues.
| Function | Description |
| Maintaining cell structure | SCEL plays a crucial role in preserving the structural integrity of epithelial cells and stem cells, ensuring their proper function and stability. |
| Cell adhesion | The Ig-like domain of SCEL facilitates cell-to-cell adhesion, contributing to tissue cohesion and organization. |
| Immune response regulation | SCEL is involved in modulating immune responses, particularly in stem cells, helping to maintain tissue homeostasis. |
| Tissue repair | SCEL contributes to tissue repair mechanisms by supporting the function of stem cells and promoting cellular regeneration. |
SCELs strong bond, with cell adhesion molecules promotes precise interactions, for preserving tissue integrity and structure.
1. Chan, Shih-Hsuan, Wen-Hung Kuo, and Lu-Hai Wang. "SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer." Journal of Biomedical Science 30.1 (2023): 93. https://doi.org/10.1186/s12929-023-00986-4
This article investigates the role of SCEL in regulating the balance between pro-survival and apoptosis in triple-negative breast cancer. SCEL antibody was used to elucidate its function in modulating the TNF-α/TNFR1/NF-κB/c-FLIP axis, demonstrating its significance in controlling lung colonization of cancer cells.
2. Li, Danping, et al. "Silencing of SCEL promotes progression of oral squamous cell carcinoma via activating TGF-β/Smad pathway." Discover Oncology 16.1 (2025): 1-19. https://doi.org/10.1007/s12672-025-02423-4
The research investigates SCEL's role in oral squamous cell carcinoma (OSCC). The research showed that SCEL silencing promotes cancer development through TGF-β/Smad pathway activation which proves its role in tumor development and its value as a therapeutic target.
Creative Biolabs specializes in the production of high-quality SCEL antibodies for research and industrial applications. Our portfolio includes monoclonal and polyclonal antibodies tailored for ELISA, Flow Cytometry, Western blot, immunohistochemistry, and other diagnostic methodologies.
For further information regarding our SCEL antibodies, custom orders, or technical assistance, please reach out to us via info@creative-biolabs.com.
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