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Mouse Anti-SCEL Recombinant Antibody (CBXS-3165) (CBMAB-S5907-CQ)

This product is a mouse antibody that recognizes SCEL. The antibody CBXS-3165 can be used for immunoassay techniques such as: ELISA, WB.
See all SCEL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3165
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa2-98 from SCEL (NP_003834) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sciellin
Introduction
The protein encoded by this gene is a precursor to the cornified envelope of terminally differentiated keratinocytes. This protein localizes to the periphery of cells and may function in the assembly or regulation of proteins in the cornified envelope. Transcript variants encoding different isoforms exist. A transcript variant utilizing an alternative polyA signal has been described in the literature, but its full-length nature has not been determined.
Entrez Gene ID
8796
UniProt ID
O95171
Alternative Names
Sciellin;
Function
May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.
Biological Process
Biological Process embryo development ending in birth or egg hatchingBy SimilarityISS:UniProtKB
Biological Process epidermis developmentBy SimilarityISS:UniProtKB
Biological Process keratinocyte differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process response to mechanical stimulusManual Assertion Based On ExperimentIEP:BHF-UCL
Cellular Location
Cytoplasm
Membrane
May become cross-linked to membrane proteins by transglutaminase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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