SLC7A11

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

Solute Carrier Family 7 Member 11

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.

Biological Process adult behaviorIEA:Ensembl
Biological Process cellular response to oxidative stressIEA:Ensembl
Biological Process dipeptide import across plasma membraneIEA:Ensembl
Biological Process glutamate homeostasisIEA:Ensembl
Biological Process glutathione metabolic processIEA:Ensembl
Biological Process glutathione transmembrane transportIEA:Ensembl
Biological Process L-glutamate import across plasma membraneIEA:Ensembl
Biological Process lens fiber cell differentiationIEA:Ensembl
Biological Process limb developmentIEA:Ensembl
Biological Process lung alveolus developmentIEA:Ensembl
Biological Process modulation of chemical synaptic transmissionIEA:Ensembl
Biological Process negative regulation of oxidative stress-induced neuron deathIEA:Ensembl
Biological Process platelet aggregationIEA:Ensembl
Biological Process regulation of AMPA glutamate receptor clusteringIEA:Ensembl
Biological Process regulation of cell population proliferationIEA:Ensembl
Biological Process regulation of cysteine metabolic processIEA:Ensembl
Biological Process regulation of glutamate metabolic processIEA:Ensembl
Biological Process regulation of glutathione biosynthetic processIEA:Ensembl
Biological Process regulation of melanin biosynthetic processIEA:Ensembl
Biological Process regulation of neutrophil apoptotic processIEA:Ensembl
Biological Process regulation of protein transportIEA:Ensembl
Biological Process regulation of synapse organizationIEA:Ensembl
Biological Process response to nicotineIEA:Ensembl
Biological Process response to organic cyclic compoundIEA:Ensembl
Biological Process response to redox stateIEA:Ensembl
Biological Process response to toxic substanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process striatum developmentIEA:Ensembl
Biological Process ventricular system developmentIEA:Ensembl
Biological Process visual learningIEA:Ensembl

Membrane