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tac1

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene.
Full Name
tachykinin, precursor 1
Function
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Biological Process
Biological Process antibacterial humoral responseIDA:UniProtKB
Biological Process antifungal humoral responseIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Biological Process cell-cell signalingTAS:ProtInc1 Publication
Biological Process cellular response to nerve growth factor stimulusIEA:Ensembl
Biological Process chemical synaptic transmissionIEA:UniProtKB-KW
Biological Process defense response to Gram-negative bacteriumIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumIDA:UniProtKB
Biological Process detection of abiotic stimulusTAS:ProtInc1 Publication
Biological Process detection of temperature stimulus involved in sensory perception of painIDA:UniProtKB
Biological Process inflammatory responseIBA:GO_Central1 Publication
Biological Process innate immune responseIDA:UniProtKB
Biological Process inseminationTAS:ProtInc1 Publication
Biological Process killing of cells of another organismIDA:UniProtKB
Biological Process negative regulation of neuron deathIGI:ARUK-UCL
Biological Process negative regulation of systemic arterial blood pressureIDA:UniProtKB
Biological Process neuropeptide signaling pathwayIEA:UniProtKB-KW
Biological Process positive regulation of cytosolic calcium ion concentrationIDA:UniProtKB1 Publication
Biological Process positive regulation of flagellated sperm motilityIDA:UniProtKB
Biological Process positive regulation of neuron deathIGI:ARUK-UCL
Biological Process positive regulation of sensory perception of painIDA:UniProtKB
Biological Process regulation of sensory perception of painIDA:UniProtKB
Biological Process response to painIEA:Ensembl
Biological Process response to yeastIDA:UniProtKB
Biological Process sensory perception of painIEA:Ensembl
Biological Process tachykinin receptor signaling pathwayIDA:UniProtKB1 Publication
Cellular Location
Secreted
PTM
Substance P
The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (PubMed:21314817).
Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME) (PubMed:6208535).

Anti-tac1 antibodies

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Target: TAC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: M09205
Application*: C
Target: TAC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Guinea pig
Clone: SP-DE4-21
Application*: E, IC, IF, P
Target: TAC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: SMPS59/1
Application*: E, IF
Target: TAC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXS-3548
Application*: E, IH
Target: TAC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXS-3410
Application*: E, IH
Target: TAC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-2974
Application*: IH
Target: TAC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXS-1746
Application*: IH
Target: TAC1
Host: Rat
Specificity: Cat, Human, Rat
Clone: CBXS-0925
Application*: IC, IF, C, P
Target: TAC1
Host: Rat
Specificity: Human, Monkey, Rat, Cat
Clone: CBXS-0924
Application*: EM, IF, P
Target: TAC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-5477
Application*: P
Target: TAC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Human
Clone: CBXS-6019
Application*: C
Target: TAC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0926
Application*: E, IH
Target: TAC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-1762
Application*: IF, C, P
Target: TAC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1761
Application*: IA, IF
Target: TAC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1760
Application*: E, P
Target: TAC1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Cattle
Clone: CBYJT-1759
Application*: IF, C, P
Target: TAC1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBWJN-1687
Application*: WB
Target: TAC1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJN-1686
Application*: WB, IC, P, E
Target: tac1
Host: Mouse
Antibody Isotype: IgG1
Specificity: C. elegans
Clone: 4.5.6
Application*: IF, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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