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Mouse Anti-TAC1 Monoclonal Antibody (SP-DE4-21) (CBMAB-1570-YC)

Provided herein is a mouse monoclonal antibody against Human TAC1. The antibody, clone SP-DE4-21, can be used for immunoassay techniques, such as ELISA, ICC, IF and IHC-P.
See all TAC1 antibodies
Published Data
Fig.1 Immunostaining showing co-localization of the SST4 receptor with substance P (SP).
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Fig.2 Protein accumulation in the mouse hippocampus was analyzed by Western blotting.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Guinea pig
Clone
SP-DE4-21
Antibody Isotype
IgG1
Application
ELISA, ICC, IF, IHC-P

Basic Information

Immunogen
Synthetic peptide corresponding to Human Substance P aa 58-68
Specificity
Human, Mouse, Rat, Guinea pig
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tachykinin, precursor 1
Introduction
Substance P is an antimicrobial peptide with antibacterial and antifungal properties, which belongs to the tachykinin peptide hormone family. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells.
Entrez Gene ID
Human6863
Mouse21333
Rat24806
Guinea pig100713032
UniProt ID
HumanP20366
MouseP41539
RatP06767
Guinea pigP67932
Alternative Names
NK2; NPK; NKNA; TAC2; Hs.2563
Function
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Biological Process
Biological Process antibacterial humoral responseIDA:UniProtKB
Biological Process antifungal humoral responseIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Biological Process cell-cell signalingTAS:ProtInc1 Publication
Biological Process cellular response to nerve growth factor stimulusIEA:Ensembl
Biological Process chemical synaptic transmissionIEA:UniProtKB-KW
Biological Process defense response to Gram-negative bacteriumIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumIDA:UniProtKB
Biological Process detection of abiotic stimulusTAS:ProtInc1 Publication
Biological Process detection of temperature stimulus involved in sensory perception of painIDA:UniProtKB
Biological Process inflammatory responseIBA:GO_Central1 Publication
Biological Process innate immune responseIDA:UniProtKB
Biological Process inseminationTAS:ProtInc1 Publication
Biological Process killing of cells of another organismIDA:UniProtKB
Biological Process negative regulation of neuron deathIGI:ARUK-UCL
Biological Process negative regulation of systemic arterial blood pressureIDA:UniProtKB
Biological Process neuropeptide signaling pathwayIEA:UniProtKB-KW
Biological Process positive regulation of cytosolic calcium ion concentrationIDA:UniProtKB1 Publication
Biological Process positive regulation of flagellated sperm motilityIDA:UniProtKB
Biological Process positive regulation of neuron deathIGI:ARUK-UCL
Biological Process positive regulation of sensory perception of painIDA:UniProtKB
Biological Process regulation of sensory perception of painIDA:UniProtKB
Biological Process response to painIEA:Ensembl
Biological Process response to yeastIDA:UniProtKB
Biological Process sensory perception of painIEA:Ensembl
Biological Process tachykinin receptor signaling pathwayIDA:UniProtKB1 Publication
Cellular Location
Secreted
PTM
Substance P
The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (PubMed:21314817).
Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME) (PubMed:6208535).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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