TRIB2

This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

TRIB2 Gene(Protein Coding) Tribbles Pseudokinase 2

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).

Biological Process negative regulation of fat cell differentiation Source:BHF-UCLBy Similarity
Biological Process negative regulation of interleukin-10 production Source:BHF-UCL1 Publication
Biological Process negative regulation of protein kinase activity Source:BHF-UCL1 Publication
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source:BHF-UCLBy Similarity
Biological Process regulation of MAP kinase activity Source:UniProtKB

Cytoplasm
Cytoplasm, cytoskeleton
May associate with the cytoskeleton.