Sign in or Register   Sign in or Register
  |  

Mouse Anti-TRIB2 Recombinant Antibody (CBYJT-4650) (CBMAB-T4184-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIB2 (Tribbles Pseudokinase 2). The antibody can be used for immunoassay techniques, such as ELISA, IP.
See all TRIB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4650
Antibody Isotype
IgG2a, κ
Application
ELISA, IP

Basic Information

Immunogen
TRIB2 (AAH02637, 1 a.a. ~ 343 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-343

Target

Full Name
TRIB2 Gene(Protein Coding) Tribbles Pseudokinase 2
Introduction
TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. TRIB2 has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
Entrez Gene ID
28951
UniProt ID
Q92519
Alternative Names
Tribbles Pseudokinase 2; TRB2; Tribbles Homolog 2 (Drosophila); Tribbles Homolog 2; GS3955; TRB-2; C5FW
Function
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).
Biological Process
Biological Process negative regulation of fat cell differentiation Source:BHF-UCLBy Similarity
Biological Process negative regulation of interleukin-10 production Source:BHF-UCL1 Publication
Biological Process negative regulation of protein kinase activity Source:BHF-UCL1 Publication
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source:BHF-UCLBy Similarity
Biological Process regulation of MAP kinase activity Source:UniProtKB
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
May associate with the cytoskeleton.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TRIB2 Recombinant Antibody (CBYJT-4650)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare