TRIOBP

TRIOBP is a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. TRIOBP interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. TRIOBP also associates with F-actin and stabilizes F-actin structures. Mutations in TRIOBP have been associated with a form of autosomal recessive nonsyndromic deafness.

Full Name

TRIO And F-Actin Binding Protein

Function

May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.

Biological Process

Biological Process actin filament organization Source:GO_Central1 Publication
Biological Process actin modification Source:UniProtKB1 Publication
Biological Process auditory receptor cell stereocilium organization Source:Ensembl
Biological Process barbed-end actin filament capping Source:UniProtKB1 Publication
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process positive regulation of substrate adhesion-dependent cell spreading Source:MGI1 Publication
Biological Process sensory perception of sound Source:Ensembl

Cellular Location

Nucleus
Cytoplasm, cytoskeleton
Localized to F-actin in a periodic pattern.
Isoform 1
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Midbody
Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.

Involvement in disease

Deafness, autosomal recessive, 28 (DFNB28):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

PTM

Ubiquitinated by HECTD3, leading to its degradation by the proteasome.
Isoform 1
Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.