Mouse Anti-TRIOBP Recombinant Antibody (2438C1a) (CBMAB-T4392-YJ)

Name: Mouse Anti-TRIOBP Recombinant Antibody (2438C1a)
SKU: CBMAB-T4392-YJ
Rating: 5 (1 reviews)

See all TRIOBP antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2438C1a

Application

Dot, WB

Immunogen

TRIOBP antibody was raised in mouse using recombinant Human Trio And F-Actin Binding Protein

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TRIO And F-Actin Binding Protein

Introduction

TRIOBP is a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. TRIOBP interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. TRIOBP also associates with F-actin and stabilizes F-actin structures. Mutations in TRIOBP have been associated with a form of autosomal recessive nonsyndromic deafness.

Entrez Gene ID

11078

UniProt ID

Q9H2D6

Alternative Names

TRIO And F-Actin Binding Protein; Trio-Associated Repeat On Actin; Protein Tara; TARA; TRIO And F-Actin-Binding Protein; Tara-Like Protein; EC 3.6.3.14; HRIHFB2122

Function

May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.

Biological Process

Biological Process actin filament organization Source:GO_Central1 Publication
Biological Process actin modification Source:UniProtKB1 Publication
Biological Process auditory receptor cell stereocilium organization Source:Ensembl
Biological Process barbed-end actin filament capping Source:UniProtKB1 Publication
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process positive regulation of substrate adhesion-dependent cell spreading Source:MGI1 Publication
Biological Process sensory perception of sound Source:Ensembl

Cellular Location

Nucleus
Cytoplasm, cytoskeleton
Localized to F-actin in a periodic pattern.
Isoform 1
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Midbody
Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.

Involvement in disease

Deafness, autosomal recessive, 28 (DFNB28):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

PTM

Ubiquitinated by HECTD3, leading to its degradation by the proteasome.
Isoform 1
Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-TRIOBP Recombinant Antibody (2438C1a)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TRIOBP Recombinant Antibody (CBYJT-4849) (CAT#: CBMAB-T4393-YJ)

Mouse Anti-TRIOBP Monoclonal Antibody (Y46C) (CAT#: CBMAB-1657-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry