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Mouse Anti-TRIOBP Recombinant Antibody (2438C1a) (CBMAB-T4392-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIOBP (TRIO And F-Actin Binding Protein). The antibody can be used for immunoassay techniques, such as Dot, WB.
See all TRIOBP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2438C1a
Antibody Isotype
IgG1
Application
Dot, WB

Basic Information

Immunogen
TRIOBP antibody was raised in mouse using recombinant Human Trio And F-Actin Binding Protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 1% BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TRIO And F-Actin Binding Protein
Introduction
TRIOBP is a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. TRIOBP interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. TRIOBP also associates with F-actin and stabilizes F-actin structures. Mutations in TRIOBP have been associated with a form of autosomal recessive nonsyndromic deafness.
Entrez Gene ID
11078
UniProt ID
Q9H2D6
Alternative Names
TRIO And F-Actin Binding Protein; Trio-Associated Repeat On Actin; Protein Tara; TARA; TRIO And F-Actin-Binding Protein; Tara-Like Protein; EC 3.6.3.14; HRIHFB2122
Function
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover.
Biological Process
Biological Process actin filament organization Source:GO_Central1 Publication
Biological Process actin modification Source:UniProtKB1 Publication
Biological Process auditory receptor cell stereocilium organization Source:Ensembl
Biological Process barbed-end actin filament capping Source:UniProtKB1 Publication
Biological Process cell cycle Source:UniProtKB-KW
Biological Process cell division Source:UniProtKB-KW
Biological Process positive regulation of substrate adhesion-dependent cell spreading Source:MGI1 Publication
Biological Process sensory perception of sound Source:Ensembl
Cellular Location
Nucleus
Cytoplasm, cytoskeleton
Localized to F-actin in a periodic pattern.
Isoform 1
Nucleus
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Midbody
Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.
Involvement in disease
Deafness, autosomal recessive, 28 (DFNB28):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
PTM
Ubiquitinated by HECTD3, leading to its degradation by the proteasome.
Isoform 1
Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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