Tubb1
This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010]
Full Name
TUBB1 Gene(Protein Coding) Tubulin Beta 1 Class VI
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Biological Process
Biological Process microtubule cytoskeleton organization Source:GO_Central1 Publication
Biological Process mitotic cell cycle Source:GO_Central1 Publication
Biological Process spindle assembly Source:Ensembl
Biological Process mitotic cell cycle Source:GO_Central1 Publication
Biological Process spindle assembly Source:Ensembl
Cellular Location
Cytoplasm, cytoskeleton
Involvement in disease
Cytoplasm, cytoskeleton:
A congenital blood disorder characterized by increased platelet size and decreased number of circulating platelets.
A congenital blood disorder characterized by increased platelet size and decreased number of circulating platelets.
PTM
Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866).
Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).
Glutamylation is also involved in cilia motility (By similarity).
Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into cilia and flagella axonemes, which is required for their stability and maintenance. Flagella glycylation controls sperm motility. Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally.
Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).
Glutamylation is also involved in cilia motility (By similarity).
Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into cilia and flagella axonemes, which is required for their stability and maintenance. Flagella glycylation controls sperm motility. Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally.
Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
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Anti-Tubb1 antibodies
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CompareTarget: TUBB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYJT-5290
Application*: E, WB, P, IF, IC, F
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 86CT4.4.4
Application*: WB, E, IH, IF
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYJT-5289
Application*: E, WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5288
Application*: IC, WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 600C2a
Application*: DB, IC, IF, WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5287
Application*: IF, P, WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5286
Application*: P, WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5285
Application*: WB, IF
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5284
Application*: WB, IF
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-5283
Application*: WB, IH
Target: TUBB1
Sensitivity: 0.0027 ng/mL
Detection Range: 0.005-1 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 20B1
Application*: E, WB, IH, F
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 15E10
Application*: E, WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Zebrafish
Clone: 22D4
Application*: E, WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Zebrafish
Clone: 8H4
Application*: E, WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 29E1
Application*: E, WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBT86
Application*: WB, P, IF, IC
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Rabbit
Clone: CBT1256
Application*: WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Zebrafish
Clone: CBT1323
Application*: WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBT4702
Application*: WB, IH, IC, F
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey, Rat
Clone: CBT4845
Application*: WB, IH, IC, F
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Zebrafish
Clone: CB388A
Application*: ELISA, WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB218A
Application*: ELISA, WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: TUB2.1
Application*: ELISA, WB, IHC
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Zebrafish
Clone: CB377
Application*: WB
Target: TUBB1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB376
Application*: WB, IHC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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