ARPC5

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Full Name

Actin Related Protein 2/3 Complex Subunit 5

Function

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079).
The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079).
In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947).
The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).

Biological Process

Actin cytoskeleton organization Source: ProtInc
Actin filament network formation Source: Ensembl
Arp2/3 complex-mediated actin nucleation Source: FlyBase
Cell migration Source: CACAO
Ephrin receptor signaling pathway Source: Reactome
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Lamellipodium organization Source: Ensembl
Maintenance of cell polarity Source: Ensembl
Membrane organization Source: Reactome
Microtubule organizing center localization Source: Ensembl
Neutrophil degranulation Source: Reactome
Orbitofrontal cortex development Source: Ensembl
Smooth muscle cell migration Source: Ensembl

Cellular Location

Cytoskeleton; Nucleus; Cell projection

PTM

Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.