Sign in or Register   Sign in or Register
  |  

Mouse Anti-ARPC5 Recombinant Antibody (2G1) (CBMAB-P0076-YC)

Provided herein is a Mouse monoclonal antibody against Human Actin Related Protein 2/3 Complex Subunit 5. The antibody can be used for immunoassay techniques, such as WB, IHC-P.
See all ARPC5 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
2G1
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human ARPC5 (NP_005708) produced in HEK293T cell.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:2,000
IHC1:150

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Actin Related Protein 2/3 Complex Subunit 5
Introduction
ARPC5 is one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene.
Entrez Gene ID
10092
UniProt ID
O15511
Alternative Names
5830443F10Rik; p16-Arc
Function
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079).
The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079).
In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947).
The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Biological Process
Actin cytoskeleton organization Source: ProtInc
Actin filament network formation Source: Ensembl
Arp2/3 complex-mediated actin nucleation Source: FlyBase
Cell migration Source: CACAO
Ephrin receptor signaling pathway Source: Reactome
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Lamellipodium organization Source: Ensembl
Maintenance of cell polarity Source: Ensembl
Membrane organization Source: Reactome
Microtubule organizing center localization Source: Ensembl
Neutrophil degranulation Source: Reactome
Orbitofrontal cortex development Source: Ensembl
Smooth muscle cell migration Source: Ensembl
Cellular Location
Cytoskeleton; Nucleus; Cell projection
PTM
Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-ARPC5 Recombinant Antibody (2G1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare