ATG9A

ATG9A is involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. ATG9A plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle.

Full Name

Autophagy Related 9A

Function

Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H.

Biological Process

Autophagosome assembly Source: MGI
Autophagy of mitochondrion Source: GO_Central
Late nucleophagy Source: GO_Central
Protein localization to phagophore assembly site Source: GO_Central
Protein transport Source: UniProtKB-KW

Cellular Location

Late endosome membrane; Trans-Golgi network membrane; Endoplasmic reticulum membrane; Autophagosome membrane. Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1.

Topology

Cytoplasmic: 2-66 aa
Helical: 67-87 aa
Lumenal: 88-131 aa
Helical: 132-152 aa
Cytoplasmic: 153-289 aa
Helical: 290-310 aa
Lumenal: 311-371 aa
Helical: 372-392 aa
Cytoplasmic: 393-400 aa
Helical: 401-421 aa
Lumenal: 422-473 aa
Helical: 474-494 aa
Cytoplasmic: 495-839 aa