BCL2L12

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

BCL2 Like 12

Apoptotic process Source: UniProtKB-KW
Inhibition of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of cellular senescence Source: Ensembl
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of extrinsic apoptotic signaling pathway Source: GO_Central

Nucleus; Membrane