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Rabbit Anti-BCL2L12 Recombinant Antibody (CBYY-0418) (CBMAB-0420-YY)

This product is rabbit antibody that recognizes BCL2L12. The antibody CBYY-0418 can be used for immunoassay techniques such as: WB, IP, IHC-P, ICC, FC
See all BCL2L12 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYY-0418
Antibody Isotype
IgG
Application
WB, IP, IHC, IF, FC

Basic Information

Immunogen
A synthesized peptide derived from human BCL2L12.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
IP1:50
IF(ICC)1:50-1:200
IHC1:50-1:200
FC1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 150mM NaCl, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BCL2 Like 12
Introduction
This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Entrez Gene ID
83596
UniProt ID
Q9HB09
Alternative Names
BCL2 Like 12; Bcl-2-Related Proline-Rich Protein; BCL2-Like 12 (Proline Rich); Bcl2-L-12; BPR;
Biological Process
Apoptotic process Source: UniProtKB-KW
Inhibition of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of cellular senescence Source: Ensembl
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of extrinsic apoptotic signaling pathway Source: GO_Central
Cellular Location
Nucleus; Membrane

Yang, G., Liu, J. Q., Mo, L. H., Luo, X. Q., Li, J., Liu, Z. Q., ... & Shi, J. B. (2020). Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils. Immunology Letters, 228, 93-102.

Nikcevic, G., Drazilov, S. S., Djurasevic, T. K., Tosic, N., Kontos, C. K., Scorilas, A., & Pavlovic, S. (2020). Complex transcriptional regulation of the BCL2L12 gene: Novel, active promoter in K562 cells. Gene, 750, 144723.

Li, H., Yang, D., & Tang, Z. (2019). Bcl2 like protein-12 suppresses Foxp3+ regulatory T cells in patients with rheumatoid arthritis. American journal of translational research, 11(5), 3048.

Ma, G., Wang, C., Lv, B., Jiang, Y., & Wang, L. (2019). Proteinase-activated receptor-2 enhances Bcl2-like protein-12 expression in lung cancer cells to suppress p53 expression. Archives of medical science: AMS, 15(5), 1147.

Chu, C. W., Yang, M. C., Chou, C. H., Huang, W. S., Hsiao, B. X., Wang, Y. T., ... & Hong, Y. R. (2018). GSK3β‑mediated Ser156 phosphorylation modulates a BH3‑like domain in BCL2L12 during TMZ‑induced apoptosis and autophagy in glioma cells. International journal of molecular medicine, 42(2), 905-918.

Chen, X., Zeng, X. H., Wang, M., Chen, L., Zhang, N., Rao, M., ... & Song, J. (2018). Bcl2-like protein 12 is required for the aberrant t helper-2 polarization in the heart by enhancing interleukin-4 expression and compromising apoptotic machinery in cd4+ t cells. Circulation, 138(22), 2559-2568.

Li, M. G., Liu, X. Y., Liu, Z. Q., Hong, J. Y., Liu, J. Q., Zhou, C. J., ... & Yang, P. C. (2018). Bcl2L12 contributes to Th2-biased inflammation in the intestinal mucosa by regulating CD4+ T cell activities. The Journal of Immunology, 201(2), 725-733.

Avgeris, M., Stamati, L., Kontos, C. K., Piatopoulou, D., Marmarinos, A., Xagorari, M., ... & Scorilas, A. (2018). BCL2L12 improves risk stratification and prediction of BFM-chemotherapy response in childhood acute lymphoblastic leukemia. Clinical Chemistry and Laboratory Medicine (CCLM), 56(12), 2104-2118.

Wu, W., Liu, S., Liang, Y., Zhou, Z., Bian, W., & Liu, X. (2017). Stress hormone cortisol enhances Bcl2 like-12 expression to inhibit p53 in hepatocellular carcinoma cells. Digestive diseases and sciences, 62(12), 3495-3500.

Guo, X., Li, M. G., Li, S. S., Liu, F. H., Liu, Z. J., & Yang, P. C. (2017). Tumor necrosis factor suppresses interleukin 10 in peripheral B cells via upregulating Bcl2‐like protein 12 in patients with inflammatory bowel disease. Cell biochemistry and function, 35(2), 77-82.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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