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Mouse Anti-BCL2L12 Recombinant Antibody (1B1) (CBMAB-A0736-LY)

The product is antibody recognizes BCL2L12. The antibody 1B1 immunoassay techniques such as: WB, ELISA.
See all BCL2L12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B1
Antibody Isotype
IgG1, κ
Application
WB, ELISA, IF

Basic Information

Immunogen
BCL2L12 (AAH07724, 174 a.a. ~ 273 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
BCL2 Like 12
Introduction
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
Entrez Gene ID
83596
UniProt ID
Q9HB09
Alternative Names
MGC120313; MGC120314; MGC120315
Biological Process
Apoptotic process Source: UniProtKB-KW
Inhibition of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
Negative regulation of cellular senescence Source: Ensembl
Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of extrinsic apoptotic signaling pathway Source: GO_Central
Cellular Location
Nucleus; Membrane

Yang, G., Liu, J. Q., Mo, L. H., Luo, X. Q., Li, J., Liu, Z. Q., ... & Shi, J. B. (2020). Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils. Immunology Letters, 228, 93-102.

Nikcevic, G., Drazilov, S. S., Djurasevic, T. K., Tosic, N., Kontos, C. K., Scorilas, A., & Pavlovic, S. (2020). Complex transcriptional regulation of the BCL2L12 gene: Novel, active promoter in K562 cells. Gene, 750, 144723.

Li, H., Yang, D., & Tang, Z. (2019). Bcl2 like protein-12 suppresses Foxp3+ regulatory T cells in patients with rheumatoid arthritis. American journal of translational research, 11(5), 3048.

Ma, G., Wang, C., Lv, B., Jiang, Y., & Wang, L. (2019). Proteinase-activated receptor-2 enhances Bcl2-like protein-12 expression in lung cancer cells to suppress p53 expression. Archives of medical science: AMS, 15(5), 1147.

Chu, C. W., Yang, M. C., Chou, C. H., Huang, W. S., Hsiao, B. X., Wang, Y. T., ... & Hong, Y. R. (2018). GSK3β‑mediated Ser156 phosphorylation modulates a BH3‑like domain in BCL2L12 during TMZ‑induced apoptosis and autophagy in glioma cells. International journal of molecular medicine, 42(2), 905-918.

Chen, X., Zeng, X. H., Wang, M., Chen, L., Zhang, N., Rao, M., ... & Song, J. (2018). Bcl2-like protein 12 is required for the aberrant t helper-2 polarization in the heart by enhancing interleukin-4 expression and compromising apoptotic machinery in cd4+ t cells. Circulation, 138(22), 2559-2568.

Li, M. G., Liu, X. Y., Liu, Z. Q., Hong, J. Y., Liu, J. Q., Zhou, C. J., ... & Yang, P. C. (2018). Bcl2L12 contributes to Th2-biased inflammation in the intestinal mucosa by regulating CD4+ T cell activities. The Journal of Immunology, 201(2), 725-733.

Avgeris, M., Stamati, L., Kontos, C. K., Piatopoulou, D., Marmarinos, A., Xagorari, M., ... & Scorilas, A. (2018). BCL2L12 improves risk stratification and prediction of BFM-chemotherapy response in childhood acute lymphoblastic leukemia. Clinical Chemistry and Laboratory Medicine (CCLM), 56(12), 2104-2118.

Wu, W., Liu, S., Liang, Y., Zhou, Z., Bian, W., & Liu, X. (2017). Stress hormone cortisol enhances Bcl2 like-12 expression to inhibit p53 in hepatocellular carcinoma cells. Digestive diseases and sciences, 62(12), 3495-3500.

Guo, X., Li, M. G., Li, S. S., Liu, F. H., Liu, Z. J., & Yang, P. C. (2017). Tumor necrosis factor suppresses interleukin 10 in peripheral B cells via upregulating Bcl2‐like protein 12 in patients with inflammatory bowel disease. Cell biochemistry and function, 35(2), 77-82.

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For research use only. Not intended for any clinical use.

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