CCK

Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. [provided by RefSeq]

Full Name

cholecystokinin

Function

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Axonogenesis Source: UniProtKB
Digestion Source: GO_Central
Eating behavior Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Memory Source: Ensembl
Negative regulation of appetite Source: Ensembl
Negative regulation of behavioral fear response Source: Ensembl
Negative regulation of eating behavior Source: Ensembl
Neuron migration Source: UniProtKB
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of behavioral fear response Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of glutamate secretion Source: Ensembl
Positive regulation of mitochondrial depolarization Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of protein-containing complex assembly Source: Ensembl
Positive regulation of sensory perception of pain Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Release of cytochrome c from mitochondria Source: Ensembl
Signal transduction Source: ProtInc
Visual learning Source: Ensembl

Cellular Location

Secreted

PTM

The precursor is cleaved by proteases to produce a number of active cholecystokinins.