CCK

Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. [provided by RefSeq]

cholecystokinin

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Axonogenesis Source: UniProtKB
Digestion Source: GO_Central
Eating behavior Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Memory Source: Ensembl
Negative regulation of appetite Source: Ensembl
Negative regulation of behavioral fear response Source: Ensembl
Negative regulation of eating behavior Source: Ensembl
Neuron migration Source: UniProtKB
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of behavioral fear response Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of glutamate secretion Source: Ensembl
Positive regulation of mitochondrial depolarization Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of protein-containing complex assembly Source: Ensembl
Positive regulation of sensory perception of pain Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Release of cytochrome c from mitochondria Source: Ensembl
Signal transduction Source: ProtInc
Visual learning Source: Ensembl

Secreted

The precursor is cleaved by proteases to produce a number of active cholecystokinins.