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Mouse Anti-CCK Recombinant Antibody (C0778) (CBMAB-C0778-LY)


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Summary

Host Animal
Mouse
Specificity
Rat
Clone
C0778
Antibody Isotype
IgG1, κ
Application
WB, IF, IHC-P

Basic Information

Immunogen
Recombinant Rat CCK protein, Met1-Ser115.
Host Species
Mouse
Specificity
Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB0.5-2 µg/ml
IF(ICC)5-20 µg/ml
IHC-P5-20 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cholecystokinin
Introduction
CCK (Cholecystokinin) is a Protein Coding gene. Diseases associated with CCK include Biliary Dyskinesia and Cholecystitis. Among its related pathways are Cell-type Dependent Selectivity of CCK2R Signaling and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity.
Entrez Gene ID
885
UniProt ID
P06307
Alternative Names
Cholecystokinin; Cholecystokinin Triacontatriapeptide; Prepro-Cholecystokinin;
Function
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Axonogenesis Source: UniProtKB
Digestion Source: GO_Central
Eating behavior Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Memory Source: Ensembl
Negative regulation of appetite Source: Ensembl
Negative regulation of behavioral fear response Source: Ensembl
Negative regulation of eating behavior Source: Ensembl
Neuron migration Source: UniProtKB
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of behavioral fear response Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of glutamate secretion Source: Ensembl
Positive regulation of mitochondrial depolarization Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of protein-containing complex assembly Source: Ensembl
Positive regulation of sensory perception of pain Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Release of cytochrome c from mitochondria Source: Ensembl
Signal transduction Source: ProtInc
Visual learning Source: Ensembl
Cellular Location
Secreted
PTM
The precursor is cleaved by proteases to produce a number of active cholecystokinins.
More Infomation

Keay, K. A., Argueta, M. A., Zafir, D. N., Wyllie, P. M., Michael, G. J., & Boorman, D. C. (2021). Evidence that increased cholecystokinin (CCK) in the periaqueductal gray (PAG) facilitates changes in Resident–Intruder social interactions triggered by peripheral nerve injury. Journal of Neurochemistry, 158(5), 1151-1171.

Gilliam-Vigh, H., Jorsal, T., Rehfeld, J. F., Pedersen, J., Poulsen, S. S., Vilsbøll, T., & Knop, F. K. (2021). Expression of Cholecystokinin and its Receptors in the Intestinal Tract of Type 2 Diabetes Patients and Healthy Controls. The Journal of Clinical Endocrinology & Metabolism, 106(8), 2164-2170.

Rehfeld, J. F. (2020). Measurement of cholecystokinin in plasma with reference to nutrition related obesity studies. Nutrition Research, 76, 1-8.

Zeng, Q., Ou, L., Wang, W., & Guo, D. Y. (2020). Gastrin, cholecystokinin, signaling, and biological activities in cellular processes. Frontiers in endocrinology, 11, 112.

Plagman, A., Hoscheidt, S., McLimans, K. E., Klinedinst, B., Pappas, C., Anantharam, V., ... & Alzheimer's Disease Neuroimaging Initiative. (2019). Cholecystokinin and Alzheimer's disease: a biomarker of metabolic function, neural integrity, and cognitive performance. Neurobiology of aging, 76, 201-207.

Le, H. T., Lie, K. K., Giroud-Argoud, J., Rønnestad, I., & Sæle, Ø. (2019). Effects of cholecystokinin (CCK) on gut motility in the stomachless fish ballan wrasse (Labrus bergylta). Frontiers in neuroscience, 13, 553.

Whissell, P. D., Bang, J. Y., Khan, I., Xie, Y. F., Parfitt, G. M., Grenon, M., ... & Kim, J. C. (2019). Selective activation of Cholecystokinin-Expressing GABA (CCK-GABA) Neurons enhances memory and cognition. Eneuro, 6(1).

Nadella, S., Burks, J., Al-Sabban, A., Inyang, G., Wang, J., Tucker, R. D., ... & Smith, J. P. (2018). Dietary fat stimulates pancreatic cancer growth and promotes fibrosis of the tumor microenvironment through the cholecystokinin receptor. American Journal of Physiology-Gastrointestinal and Liver Physiology, 315(5), G699-G712.

Pathak, V., Flatt, P. R., & Irwin, N. (2018). Cholecystokinin (CCK) and related adjunct peptide therapies for the treatment of obesity and type 2 diabetes. Peptides, 100, 229-235.

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For research use only. Not intended for any clinical use.

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