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Rabbit Anti-CCK Recombinant Antibody (CBFYC-0916) (CBMAB-C0972-FY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYC-0916
Antibody Isotype
IgG
Application
IHC, IF

Basic Information

Immunogen
Human CCK synthetic peptide.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)3-25 µg/ml
IHC3-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
cholecystokinin
Introduction
This gene encodes a member of the gastrin/cholecystokinin family of proteins.
Entrez Gene ID
885
UniProt ID
P06307
Alternative Names
CCK8; Cholecystokinin 8; Sincalide
Function
This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Axonogenesis Source: UniProtKB
Digestion Source: GO_Central
Eating behavior Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Memory Source: Ensembl
Negative regulation of appetite Source: Ensembl
Negative regulation of behavioral fear response Source: Ensembl
Negative regulation of eating behavior Source: Ensembl
Neuron migration Source: UniProtKB
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of behavioral fear response Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of glutamate secretion Source: Ensembl
Positive regulation of mitochondrial depolarization Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
Positive regulation of protein-containing complex assembly Source: Ensembl
Positive regulation of sensory perception of pain Source: Ensembl
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Release of cytochrome c from mitochondria Source: Ensembl
Signal transduction Source: ProtInc
Visual learning Source: Ensembl
Cellular Location
Secreted
PTM
The precursor is cleaved by proteases to produce a number of active cholecystokinins.
More Infomation

Keay, K. A., Argueta, M. A., Zafir, D. N., Wyllie, P. M., Michael, G. J., & Boorman, D. C. (2021). Evidence that increased cholecystokinin (CCK) in the periaqueductal gray (PAG) facilitates changes in Resident–Intruder social interactions triggered by peripheral nerve injury. Journal of Neurochemistry, 158(5), 1151-1171.

Gilliam-Vigh, H., Jorsal, T., Rehfeld, J. F., Pedersen, J., Poulsen, S. S., Vilsbøll, T., & Knop, F. K. (2021). Expression of Cholecystokinin and its Receptors in the Intestinal Tract of Type 2 Diabetes Patients and Healthy Controls. The Journal of Clinical Endocrinology & Metabolism, 106(8), 2164-2170.

Rehfeld, J. F. (2020). Measurement of cholecystokinin in plasma with reference to nutrition related obesity studies. Nutrition Research, 76, 1-8.

Zeng, Q., Ou, L., Wang, W., & Guo, D. Y. (2020). Gastrin, cholecystokinin, signaling, and biological activities in cellular processes. Frontiers in endocrinology, 11, 112.

Plagman, A., Hoscheidt, S., McLimans, K. E., Klinedinst, B., Pappas, C., Anantharam, V., ... & Alzheimer's Disease Neuroimaging Initiative. (2019). Cholecystokinin and Alzheimer's disease: a biomarker of metabolic function, neural integrity, and cognitive performance. Neurobiology of aging, 76, 201-207.

Le, H. T., Lie, K. K., Giroud-Argoud, J., Rønnestad, I., & Sæle, Ø. (2019). Effects of cholecystokinin (CCK) on gut motility in the stomachless fish ballan wrasse (Labrus bergylta). Frontiers in neuroscience, 13, 553.

Whissell, P. D., Bang, J. Y., Khan, I., Xie, Y. F., Parfitt, G. M., Grenon, M., ... & Kim, J. C. (2019). Selective activation of Cholecystokinin-Expressing GABA (CCK-GABA) Neurons enhances memory and cognition. Eneuro, 6(1).

Nadella, S., Burks, J., Al-Sabban, A., Inyang, G., Wang, J., Tucker, R. D., ... & Smith, J. P. (2018). Dietary fat stimulates pancreatic cancer growth and promotes fibrosis of the tumor microenvironment through the cholecystokinin receptor. American Journal of Physiology-Gastrointestinal and Liver Physiology, 315(5), G699-G712.

Pathak, V., Flatt, P. R., & Irwin, N. (2018). Cholecystokinin (CCK) and related adjunct peptide therapies for the treatment of obesity and type 2 diabetes. Peptides, 100, 229-235.

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For research use only. Not intended for any clinical use.

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