CNMD

CNN2 (Calponin 2) is a Protein Coding gene.

Full Name

Chondromodulin

Function

Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.

Biological Process

Cartilage development Source: UniProtKB-KW
Endothelial cell morphogenesis Source: GO_Central
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of endothelial cell proliferation Source: GO_Central
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: GO_Central
Proteoglycan metabolic process Source: ProtInc
Skeletal system development Source: ProtInc

Cellular Location

Chondromodulin-1: Extracellular matrix. Accumulated in the inter-territorial matrix of cartilage.
Chondrosurfactant protein: Endomembrane system

Topology

Helical: 45-65

PTM

After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.