CNMD

CNN2 (Calponin 2) is a Protein Coding gene.
Full Name
Chondromodulin
Function
Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.
Biological Process
Cartilage development Source: UniProtKB-KW
Endothelial cell morphogenesis Source: GO_Central
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of endothelial cell proliferation Source: GO_Central
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: GO_Central
Proteoglycan metabolic process Source: ProtInc
Skeletal system development Source: ProtInc
Cellular Location
Chondromodulin-1: Extracellular matrix. Accumulated in the inter-territorial matrix of cartilage.
Chondrosurfactant protein: Endomembrane system
Topology
Helical: 45-65
PTM
After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
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Anti-CNMD antibodies

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Mouse Anti-CNMD Recombinant Antibody (CBYY-C0053) (CBMAB-C0165-YY)

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Target: CNMD
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Clone: CBYY-C0053
Application*: WB, IP, IF, E
Datasheet SDS

Human CNMD ELISA Kit (V2LY-0626-LY2752)

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Target: CNMD
Sensitivity: 0.05 ng/mL
Detection Range: 0.1-30 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant LECT1 protein, hFc Tag (V2LY-0526-LY5279)

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Target: CNMD
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 215-333
Tag: hFc Tag
Datasheet SDS

Mouse Anti-CNMD Recombinant Antibody (C0173) (V2LY-1206-LY427)

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Target: CNMD
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: C0173
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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