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Mouse Anti-CNMD Recombinant Antibody (CBYY-C0053) (CBMAB-C0165-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Clone
CBYY-C0053
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 1-300 mapping at the N-terminus of ChM-1 of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Horse, Dog, Cattle, Pig
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
<0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chondromodulin
Entrez Gene ID
Human11061
Mouse16840
Rat81512
UniProt ID
HumanO75829
MouseQ9Z1F6
RatO70367
Alternative Names
CD1a Molecule; T-Cell Surface Antigen T6/Leu-6; CD1A Antigen, A Polypeptide; HTa1 Thymocyte Antigen; CD1a Antigen; Epidermal Dendritic Cell Marker CD1a; Differentiation Antigen CD1-Alpha-3; T-Cell Surface Glycoprotein CD1a;
Function
Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.
Biological Process
Cartilage development Source: UniProtKB-KW
Endothelial cell morphogenesis Source: GO_Central
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of endothelial cell proliferation Source: GO_Central
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: GO_Central
Proteoglycan metabolic process Source: ProtInc
Skeletal system development Source: ProtInc
Cellular Location
Chondromodulin-1: Extracellular matrix. Accumulated in the inter-territorial matrix of cartilage.
Chondrosurfactant protein: Endomembrane system
Topology
Helical: 45-65
PTM
After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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