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Mouse Anti-CNMD Recombinant Antibody (C0173) (V2LY-1206-LY427)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
C0173
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Recombinant human Chondrolectin, Arg22-Asn216.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Chondromodulin
Entrez Gene ID
11061
UniProt ID
O75829
Function
Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.
Biological Process
Cartilage development Source: UniProtKB-KW
Endothelial cell morphogenesis Source: GO_Central
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of endothelial cell proliferation Source: GO_Central
Negative regulation of vascular endothelial growth factor receptor signaling pathway Source: GO_Central
Proteoglycan metabolic process Source: ProtInc
Skeletal system development Source: ProtInc
Cellular Location
Chondromodulin-1: Extracellular matrix. Accumulated in the inter-territorial matrix of cartilage.
Chondrosurfactant protein: Endomembrane system
Topology
Helical: 45-65
PTM
After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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