CYP2D6

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Cytochrome P450 Family 2 Subfamily D Member 6

A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599).

Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:19965576, PubMed:20972997).

Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:18698000, PubMed:21289075).

Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599).

Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid (PubMed:10681376).

Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.

Alkaloid catabolic process Source: BHF-UCL
Alkaloid metabolic process Source: BHF-UCL
Arachidonic acid metabolic process Source: GO_Central
Cholesterol metabolic process Source: UniProtKB-UniPathway
Coumarin metabolic process Source: BHF-UCL
Drug catabolic process Source: BHF-UCL
Drug metabolic process Source: BHF-UCL
Estrogen metabolic process Source: UniProtKB
Exogenous drug catabolic process Source: GO_Central
Heterocycle metabolic process Source: BHF-UCL
Isoquinoline alkaloid metabolic process Source: BHF-UCL
Long-chain fatty acid biosynthetic process Source: Reactome
Monoterpenoid metabolic process Source: BHF-UCL
Negative regulation of binding Source: BHF-UCL
Negative regulation of cellular organofluorine metabolic process Source: BHF-UCL
Organic acid metabolic process Source: GO_Central
Oxidative demethylation Source: BHF-UCL
Retinol metabolic process Source: UniProtKB
Steroid metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: GO_Central

Endoplasmic reticulum membrane; Microsome membrane