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Mouse Anti-CYP2D6 Recombinant Antibody (CBXC-3080) (V2LY-0125-LY959)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-3080
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
Cytochrome P450, family 2, subfamily D, polypeptide 6.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Glycerol & PBS
Preservative
Sodium Azide
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cytochrome P450 Family 2 Subfamily D Member 6
Entrez Gene ID
1565
UniProt ID
P10635
Function
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599).

Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599).

Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:19965576, PubMed:20972997).

Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:18698000, PubMed:21289075).

Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599).

Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid (PubMed:10681376).

Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Biological Process
Alkaloid catabolic process Source: BHF-UCL
Alkaloid metabolic process Source: BHF-UCL
Arachidonic acid metabolic process Source: GO_Central
Cholesterol metabolic process Source: UniProtKB-UniPathway
Coumarin metabolic process Source: BHF-UCL
Drug catabolic process Source: BHF-UCL
Drug metabolic process Source: BHF-UCL
Estrogen metabolic process Source: UniProtKB
Exogenous drug catabolic process Source: GO_Central
Heterocycle metabolic process Source: BHF-UCL
Isoquinoline alkaloid metabolic process Source: BHF-UCL
Long-chain fatty acid biosynthetic process Source: Reactome
Monoterpenoid metabolic process Source: BHF-UCL
Negative regulation of binding Source: BHF-UCL
Negative regulation of cellular organofluorine metabolic process Source: BHF-UCL
Organic acid metabolic process Source: GO_Central
Oxidative demethylation Source: BHF-UCL
Retinol metabolic process Source: UniProtKB
Steroid metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: GO_Central
Cellular Location
Endoplasmic reticulum membrane; Microsome membrane
More Infomation

van der Lee, M., Allard, W. G., Vossen, R. H., Baak-Pablo, R. F., Menafra, R., Deiman, B. A., ... & Anvar, S. Y. (2021). Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data. Science translational medicine, 13(603), eabf3637.

Koopmans, A. B., Braakman, M. H., Vinkers, D. J., Hoek, H. W., & van Harten, P. N. (2021). Meta-analysis of probability estimates of worldwide variation of CYP2D6 and CYP2C19. Translational psychiatry, 11(1), 1-16.

Nofziger, C., Turner, A. J., Sangkuhl, K., Whirl‐Carrillo, M., Agúndez, J. A., Black, J. L., ... & Gaedigk, A. (2020). PharmVar GeneFocus: CYP2D6. Clinical Pharmacology & Therapeutics, 107(1), 154-170.

Taylor, C., Crosby, I., Yip, V., Maguire, P., Pirmohamed, M., & Turner, R. M. (2020). A Review of the Important Role of CYP2D6 in Pharmacogenomics. Genes, 11(11), 1295.

Smith, D. M., Weitzel, K. W., Elsey, A. R., Langaee, T., Gong, Y., Wake, D. T., ... & Cavallari, L. H. (2019). CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial. Genetics in Medicine, 21(8), 1842-1850.

Del Tredici, A. L., Malhotra, A., Dedek, M., Espin, F., Roach, D., Zhu, G. D., ... & Moreno, T. A. (2018). Frequency of CYP2D6 alleles including structural variants in the United States. Frontiers in pharmacology, 9, 305.

Gaedigk, A., Dinh, J. C., Jeong, H., Prasad, B., & Leeder, J. S. (2018). Ten years’ experience with the CYP2D6 activity score: a perspective on future investigations to improve clinical predictions for precision therapeutics. Journal of personalized medicine, 8(2), 15.

Pan, X., Ning, M., & Jeong, H. (2017). Transcriptional regulation of CYP2D6 expression. Drug Metabolism and Disposition, 45(1), 42-48.

Gaedigk, A., Sangkuhl, K., Whirl-Carrillo, M., Klein, T., & Leeder, J. S. (2017). Prediction of CYP2D6 phenotype from genotype across world populations. Genetics in Medicine, 19(1), 69-76.

Dean, L. (2017). Codeine therapy and CYP2D6 genotype.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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