DLL3

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
Full Name
Delta Like Canonical Notch Ligand 3
Function
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Biological Process
Compartment pattern specification Source: Ensembl
Negative regulation of neurogenesis Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Paraxial mesoderm development Source: Ensembl
Skeletal system development Source: UniProtKB
Somitogenesis Source: Ensembl
Cellular Location
Membrane
Involvement in disease
Spondylocostal dysostosis 1, autosomal recessive (SCDO1):
A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
Topology
Extracellular: 27-492
Helical: 493-513
Cytoplasmic: 514-618
PTM
Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
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Anti-DLL3 antibodies

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Rabbit Anti-DLL3 Recombinant Antibody (E3J5R) (CBMAB-CP0471-LY)

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Target: DLL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E3J5R
Application*: WB, IP, P
Datasheet SDS

Mouse Anti-DLL3 Recombinant Antibody (CBYCD-307) (CBMAB-D1085-YC)

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Target: DLL3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYCD-307
Application*: WB
Datasheet SDS

Mouse Anti-DLL3 Recombinant Antibody (CBT4515) (V2LY-0625-LY1905)

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Target: DLL3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4515
Application*: IH, F
Datasheet SDS

Mouse Anti-DLL3 Recombinant Antibody (CBT3899) (V2LY-0625-LY1819)

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Target: DLL3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: CBT3899
Application*: WB, IH, IC, F
Datasheet SDS

Rabbit Anti-DLL3 Monoclonal Antibody (CBFYR-0016) (V2LY-0425-LY488)

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Target: DLL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYR-0016
Application*: WB, IP, IH
Datasheet SDS

Human Anti-DLL3 Recombinant Antibody (CP0471) (V2LY-0425-LY487)

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Target: DLL3
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CP0471
Application*: E, F
Datasheet SDS

Human Anti-DLL3 Recombinant Antibody (CBYCD-307) (V2LY-0425-LY486)

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Target: DLL3
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCD-307
Application*: E, F
Datasheet SDS

Rabbit Anti-DLL3 Monoclonal Antibody (CBFYR-0016) (CBMAB-R0028-FY)

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Target: DLL3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYR-0016
Application*: ELISA
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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