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Mouse Anti-DLL3 Recombinant Antibody (CBYCD-307) (CBMAB-D1085-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCD-307
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
CHO-derived recombinant human DLL3, Ala27-Pro488, Accession # Q9NYJ7
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Delta Like Canonical Notch Ligand 3
Introduction
DLL3 belongs to the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
Entrez Gene ID
10683
UniProt ID
Q9NYJ7
Alternative Names
Delta Like Canonical Notch Ligand 3; Drosophila Delta Homolog 3; Delta3; Delta (Drosophila)-Like 3; Delta-Like 3 (Drosophila); Delta-Like Protein 3; Delta-Like 3; SCDO1;
Function
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Biological Process
Compartment pattern specification Source: Ensembl
Negative regulation of neurogenesis Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Paraxial mesoderm development Source: Ensembl
Skeletal system development Source: UniProtKB
Somitogenesis Source: Ensembl
Cellular Location
Membrane
Involvement in disease
Spondylocostal dysostosis 1, autosomal recessive (SCDO1):
A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
Topology
Extracellular: 27-492
Helical: 493-513
Cytoplasmic: 514-618
PTM
Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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