Mouse Dll3 ELISA Kit (V2LY-0626-LY1615)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0092 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
62.1 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Delta Like Canonical Notch Ligand 3
Function
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Biological Process
Compartment pattern specification Source: Ensembl
Negative regulation of neurogenesis Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Paraxial mesoderm development Source: Ensembl
Skeletal system development Source: UniProtKB
Somitogenesis Source: Ensembl
Cellular Location
Membrane
Involvement in disease
Spondylocostal dysostosis 1, autosomal recessive (SCDO1):
A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
Topology
Extracellular: 27-492
Helical: 493-513
Cytoplasmic: 514-618
PTM
Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.

Matsuo, K., Taniguchi, K., Hamamoto, H., Inomata, Y., Komura, K., Tanaka, T., ... & Uchiyama, K. (2021). Delta‐like canonical Notch ligand 3 as a potential therapeutic target in malignancies: a brief overview. Cancer Science, 112(8), 2984.

Matsuo, K., Taniguchi, K., Hamamoto, H., Ito, Y., Futaki, S., Inomata, Y., ... & Uchiyama, K. (2019). Delta‐like 3 localizes to neuroendocrine cells and plays a pivotal role in gastrointestinal neuroendocrine malignancy. Cancer science, 110(10), 3122-3131.

Deng, S. M., Yan, X. C., Liang, L., Wang, L., Liu, Y., Duan, J. L., ... & Han, H. (2017). The Notch ligand delta-like 3 promotes tumor growth and inhibits Notch signaling in lung cancer cells in mice. Biochemical and biophysical research communications, 483(1), 488-494.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY1233)

Cynomolgus Recombinant DLL3 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1482)

Cynomolgus Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY1483)

Human Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY3588)

Human Recombinant DLL3 (C-Llama-Fc) protein (CAT#: V2LY-0526-LY3589)

Human Recombinant DLL3 protein, ECD, His Tag (CAT#: V2LY-0526-LY3590)

Mouse Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY8203)

Rhesus Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY9704)

Human DLL3 ELISA Kit (CAT#: V2LY-0626-LY3726)

Related Products

Mouse Anti-DLL3 Recombinant Antibody (CBYCD-307) (CAT#: CBMAB-D1085-YC)

Human Anti-DLL3 Recombinant Antibody (CP0471) (CAT#: V2LY-0425-LY487)

Mouse Anti-DLL3 Recombinant Antibody (CBT3899) (CAT#: V2LY-0625-LY1819)

Rabbit Anti-DLL3 Monoclonal Antibody (CBFYR-0016) (CAT#: V2LY-0425-LY488)

Rabbit Anti-DLL3 Monoclonal Antibody (CBFYR-0016) (CAT#: CBMAB-R0028-FY)

Human Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY3588)

Human DLL3 ELISA Kit (CAT#: V2LY-0626-LY3726)

Human Anti-DLL3 Recombinant Antibody (
7B7) (CAT#: V2LY-0725-LY1430)

Human Anti-DLL3 Recombinant Antibody (CBYCD-307) (CAT#: V2LY-0425-LY486)

Cynomolgus Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY1483)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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