Human Recombinant DLL3 protein, His Tag (V2LY-0526-LY3588)

Name: Human Recombinant DLL3 protein, His Tag
SKU: V2LY-0526-LY3588
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant DLL3 protein, His Tag consist of Amino Acid: 312-492 and predicts a molecular mass of 20.7 kDa.

Molecule Mass

20.7 kDa

Sequence

Amino Acid: 312-492

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Delta Like Canonical Notch Ligand 3

Function

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).

Biological Process

Compartment pattern specification Source: Ensembl
Negative regulation of neurogenesis Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Paraxial mesoderm development Source: Ensembl
Skeletal system development Source: UniProtKB
Somitogenesis Source: Ensembl

Cellular Location

Membrane

Involvement in disease

Spondylocostal dysostosis 1, autosomal recessive (SCDO1):
A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.

Topology

Extracellular: 27-492
Helical: 493-513
Cytoplasmic: 514-618

PTM

Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.

Matsuo, K., Taniguchi, K., Hamamoto, H., Inomata, Y., Komura, K., Tanaka, T., ... & Uchiyama, K. (2021). Delta‐like canonical Notch ligand 3 as a potential therapeutic target in malignancies: a brief overview. Cancer Science, 112(8), 2984.

Matsuo, K., Taniguchi, K., Hamamoto, H., Ito, Y., Futaki, S., Inomata, Y., ... & Uchiyama, K. (2019). Delta‐like 3 localizes to neuroendocrine cells and plays a pivotal role in gastrointestinal neuroendocrine malignancy. Cancer science, 110(10), 3122-3131.

Deng, S. M., Yan, X. C., Liang, L., Wang, L., Liu, Y., Duan, J. L., ... & Han, H. (2017). The Notch ligand delta-like 3 promotes tumor growth and inhibits Notch signaling in lung cancer cells in mice. Biochemical and biophysical research communications, 483(1), 488-494.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY1233)

Cynomolgus Recombinant DLL3 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1482)

Cynomolgus Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY1483)

Human Recombinant DLL3 (C-Llama-Fc) protein (CAT#: V2LY-0526-LY3589)

Human Recombinant DLL3 protein, ECD, His Tag (CAT#: V2LY-0526-LY3590)

Mouse Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY8203)

Rhesus Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY9704)

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Canine Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY1233)

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Cynomolgus Recombinant DLL3 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY1482)

Mouse Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY8203)

Mouse Anti-DLL3 Recombinant Antibody (CBYCD-307) (CAT#: CBMAB-D1085-YC)

Human Anti-DLL3 Recombinant Antibody (CP0471) (CAT#: V2LY-0425-LY487)

Human Recombinant DLL3 protein, ECD, His Tag (CAT#: V2LY-0526-LY3590)

Rabbit Anti-DLL3 Recombinant Antibody (E3J5R) (CAT#: CBMAB-CP0471-LY)

Cynomolgus Recombinant DLL3 protein, His Tag (CAT#: V2LY-0526-LY1483)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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