Rabbit Anti-DLL3 Monoclonal Antibody (CBFYR-0016) (CBMAB-R0028-FY)

Name: Rabbit Anti-DLL3 Monoclonal Antibody (CBFYR-0016)
SKU: CBMAB-R0028-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBFYR-0016

Application

ELISA

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Purity

> 90% Purity determined by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Delta Like Canonical Notch Ligand 3

Introduction

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

Entrez Gene ID

10683

UniProt ID

Q9NYJ7

Alternative Names

Delta Like Canonical Notch Ligand 3; Drosophila Delta Homolog 3; Delta3; Delta (Drosophila)-Like 3; Delta-Like 3 (Drosophila); Delta-Like Protein 3; Delta-Like 3; SCDO1

Function

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).

Biological Process

Compartment pattern specification Source: Ensembl
Negative regulation of neurogenesis Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Paraxial mesoderm development Source: Ensembl
Skeletal system development Source: UniProtKB
Somitogenesis Source: Ensembl

Cellular Location

Membrane

Involvement in disease

Spondylocostal dysostosis 1, autosomal recessive (SCDO1):
A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.

Topology

Extracellular: 27-492
Helical: 493-513
Cytoplasmic: 514-618

PTM

Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.

Matsuo, K., Taniguchi, K., Hamamoto, H., Inomata, Y., Komura, K., Tanaka, T., ... & Uchiyama, K. (2021). Delta‐like canonical Notch ligand 3 as a potential therapeutic target in malignancies: a brief overview. Cancer Science, 112(8), 2984.

Matsuo, K., Taniguchi, K., Hamamoto, H., Ito, Y., Futaki, S., Inomata, Y., ... & Uchiyama, K. (2019). Delta‐like 3 localizes to neuroendocrine cells and plays a pivotal role in gastrointestinal neuroendocrine malignancy. Cancer science, 110(10), 3122-3131.

Deng, S. M., Yan, X. C., Liang, L., Wang, L., Liu, Y., Duan, J. L., ... & Han, H. (2017). The Notch ligand delta-like 3 promotes tumor growth and inhibits Notch signaling in lung cancer cells in mice. Biochemical and biophysical research communications, 483(1), 488-494.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rabbit Anti-DLL3 Monoclonal Antibody (CBFYR-0016) (CAT#: V2LY-0425-LY488)

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Rabbit Anti-DLL3 Recombinant Antibody (E3J5R) (CAT#: CBMAB-CP0471-LY)

Human Anti-DLL3 Recombinant Antibody (CBYCD-307) (CAT#: V2LY-0425-LY486)

Mouse Anti-DLL3 Recombinant Antibody (CBT4515) (CAT#: V2LY-0625-LY1905)

Rabbit Anti-DLL3 Monoclonal Antibody (CBFYR-0016) (CAT#: V2LY-0425-LY488)

Human Anti-DLL3 Recombinant Antibody (CP0471) (CAT#: V2LY-0425-LY487)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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