Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Rabbit Anti-DLL3 Monoclonal Antibody (CBFYR-0016) (CBMAB-R0028-FY)


See all DLL3 antibodies
Online Inquiry

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBFYR-0016
Antibody Isotype
IgG
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Purity
> 90% Purity determined by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Delta Like Canonical Notch Ligand 3
Introduction
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.
Entrez Gene ID
10683
UniProt ID
Q9NYJ7
Alternative Names
Delta Like Canonical Notch Ligand 3; Drosophila Delta Homolog 3; Delta3; Delta (Drosophila)-Like 3; Delta-Like 3 (Drosophila); Delta-Like Protein 3; Delta-Like 3; SCDO1
Function
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Biological Process
Compartment pattern specification Source: Ensembl
Negative regulation of neurogenesis Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
Paraxial mesoderm development Source: Ensembl
Skeletal system development Source: UniProtKB
Somitogenesis Source: Ensembl
Cellular Location
Membrane
Involvement in disease
Spondylocostal dysostosis 1, autosomal recessive (SCDO1):
A condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
Topology
Extracellular: 27-492
Helical: 493-513
Cytoplasmic: 514-618
PTM
Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-DLL3 Monoclonal Antibody (CBFYR-0016)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry