DLX4

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]
Full Name
Distal-Less Homeobox 4
Function
May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.
Biological Process
Cell differentiation Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Non-syndromic orofacial cleft 15 (OFC15):
A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC15 inheritance is autosomal dominant.
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Anti-DLX4 antibodies

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Mouse Anti-DLX4 Recombinant Antibody (8A1) (CBMAB-D1140-YC)

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Target: DLX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8A1
Application*: IH, WB
Datasheet SDS

Mouse Anti-DLX4 Recombinant Antibody (7H10) (CBMAB-D1139-YC)

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Target: DLX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H10
Application*: WB
Datasheet SDS

Mouse Anti-DLX4 Recombinant Antibody (7C8) (CBMAB-D1138-YC)

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Target: DLX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7C8
Application*: WB, IH
Datasheet SDS

Mouse Anti-DLX4 Recombinant Antibody (1F11) (CBMAB-D1136-YC)

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Target: DLX4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F11
Application*: WB
Datasheet SDS

Mouse Anti-DLX4 Recombinant Antibody (8A1) (V2LY-0425-LY527)

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Target: DLX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8A1
Application*: IH, WB
Datasheet SDS

Mouse Anti-DLX4 Recombinant Antibody (7H10) (V2LY-0425-LY526)

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Target: DLX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H10
Application*: WB
Datasheet SDS

Mouse Anti-DLX4 Recombinant Antibody (7C8) (V2LY-0425-LY525)

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Target: DLX4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7C8
Application*: WB, IH
Datasheet SDS

Mouse Anti-DLX4 Recombinant Antibody (1F11) (V2LY-0425-LY524)

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Target: DLX4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F11
Application*: E, WB, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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