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Mouse Anti-DLX4 Recombinant Antibody (1F11) (CBMAB-D1136-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Distal-Less Homeobox 4 (DLX4). The antibody can be used for immunoassay techniques, such as WB.
See all DLX4 antibodies
Published Data
Fig.1 DLX4 expression in normal ovary and epithelial ovarian tumors.
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Fig.2 Induction of VEGF expression by DLX4.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
1F11
Antibody Isotype
IgG2a, κ
Application
WB

Basic Information

Immunogen
DLX4 (AAH16145, 1 a.a. ~ 99 a.a) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Distal-Less Homeobox 4
Introduction
Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.
Entrez Gene ID
1748
UniProt ID
Q92988
Alternative Names
Distal-Less Homeobox 4; Homeobox Protein DLX-7; Homeobox Protein DLX-8; Beta Protein 1; DLX7; DLX9; DLX8;
Function
May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.
Biological Process
Cell differentiation Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Non-syndromic orofacial cleft 15 (OFC15):
A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC15 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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