Mouse Anti-DLX4 Recombinant Antibody (8A1) (V2LY-0425-LY527)

Name: Mouse Anti-DLX4 Recombinant Antibody (8A1)
SKU: V2LY-0425-LY527
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

8A1

Antibody Isotype

IgG1

Application

IHC, WB

Basic Information

Immunogen

Full length human recombinant protein of human DLX4 produced in E.coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
IHC	1:150
WB	1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

BSA & Glycerol & PBS

Preservative

Sodium Azide

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Distal-Less Homeobox 4

Entrez Gene ID

1748

UniProt ID

Q92988

Function

May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.

Biological Process

Cell differentiation Source: GO_Central
Negative regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Non-syndromic orofacial cleft 15 (OFC15):
A birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC15 inheritance is autosomal dominant.

More Infomation

References

Sun, G., Ge, Y., Zhang, Y., Yan, L., Wu, X., Ouyang, W., ... & Ye, Z. (2021). Transcription Factors BARX1 and DLX4 Contribute to Progression of Clear Cell Renal Cell Carcinoma via Promoting Proliferation and Epithelial–Mesenchymal Transition. Frontiers in molecular biosciences, 8, 453.

Ling, Z., Long, X., Li, J., & Feng, M. (2020). Homeodomain protein DLX4 facilitates nasopharyngeal carcinoma progression via up‐regulation of YB‐1. Genes to Cells, 25(7), 466-474.

Zhang, L., Wan, Y., Jiang, Y., Zhang, Z., Shu, S., Cheng, W., & Lang, J. (2019). Overexpression of BP1, an isoform of Homeobox Gene DLX4, promotes cell proliferation, migration and predicts poor prognosis in endometrial cancer. Gene, 707, 216-223.

Bhattacharya, S., Duverger, O., Brooks, S. R., & Morasso, M. I. (2018). Homeobox transcription factor DLX 4 is not necessary for skin development and homeostasis. Experimental dermatology, 27(3), 289-292.

Jeong, J., Naab, T. J., Fernandez, A. I., Ongkeko, M. S., Makambi, K. H., & Blancato, J. K. (2018). Homeoprotein DLX4 expression is increased in inflammatory breast cancer cases from an urban African-American population. Oncotarget, 9(58), 31253.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Mouse Anti-DLX4 Recombinant Antibody (8A1)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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