EIF4A2

EIF4A2 (Eukaryotic Translation Initiation Factor 4A2) is a Protein Coding gene. Diseases associated with EIF4A2 include Retinitis Pigmentosa 29 and X-Linked Hereditary Ataxia. Among its related pathways are Translation Translation regulation by Alpha-1 adrenergic receptors and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is EIF4A1.

Eukaryotic Translation Initiation Factor 4A2

ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Cellular response to leukemia inhibitory factor Source: Ensembl
Cytoplasmic translational initiation Source: GO_Central
Negative regulation of RNA-directed 5'-3' RNA polymerase activity Source: AgBase
Regulation of translational initiation Source: ProtInc

Cytosol; Eukaryotic translation initiation factor 4F complex; Perinuclear region of cytoplasm