Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-EIF4A2 Monoclonal Antibody (2B5) (V2LY-0425-LY1715)


See all EIF4A2 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Chicken, Human, Mouse, Rat, Frog, Zebrafish
Clone
2B5
Antibody Isotype
IgG2c
Application
IP

Basic Information

Immunogen
Full length of recombinant protein.
Host Species
Mouse
Specificity
Chicken, Human, Mouse, Rat, Frog, Zebrafish
Antibody Isotype
IgG2c
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
9775
UniProt ID
P38919
Research Area
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Biological Process
Cellular response to leukemia inhibitory factor Source: Ensembl
Cytoplasmic translational initiation Source: GO_Central
Negative regulation of RNA-directed 5'-3' RNA polymerase activity Source: AgBase
Regulation of translational initiation Source: ProtInc
Cellular Location
Cytosol; Eukaryotic translation initiation factor 4F complex; Perinuclear region of cytoplasm
More Infomation

Li, D., Yang, J., Huang, X., Zhou, H., & Wang, J. (2022). eIF4A2 targets developmental potency and histone H3. 3 transcripts for translational control of stem cell pluripotency. Science advances, 8(13), eabm0478.

Zhang, Z., Peng, M., Wen, Y., Chai, Y., Liang, J., Yang, P., ... & Huang, Y. (2022). Copy number variation of EIF4A2 loci related to phenotypic traits in Chinese cattle. Veterinary Medicine and Science.

Alwaqfi, R. R., Davick, J. J., & Bossler, A. D. (2022). EIF4A2 as another novel fusion partner of PLAG1 in lipoblastoma. Human Pathology Reports, 27, 300582.

Bolland, H. (2020). eIF4A2 is a regulator of hypoxic translation and colorectal tumour cell survival (Doctoral dissertation, University of Nottingham).

Lyu, S., Lu, J., Chen, W., Huang, W., Huang, H., Xi, S., & Yan, S. (2020). High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma. Oncology Letters, 20(5), 1-1.

Song, Z., Yang, Y., Wang, L., Wang, K., Ran, L., Xie, Y., ... & Yu, Q. (2019). EIF4A2 interacts with the membrane protein of transmissible gastroenteritis coronavirus and plays a role in virus replication. Research in veterinary science, 123, 39-46.

Wilczynska, A., Gillen, S. L., Schmidt, T., Meijer, H. A., Jukes-Jones, R., Langlais, C., ... & Bushell, M. (2019). eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5′ UTR. Genome biology, 20(1), 1-21.

Liu, M., Gong, C., Xu, R., Chen, Y., & Wang, X. (2019). MicroRNA-5195-3p enhances the chemosensitivity of triple-negative breast cancer to paclitaxel by downregulating EIF4A2. Cellular & Molecular Biology Letters, 24(1), 1-11.

Meijer, H. A., Schmidt, T., Gillen, S. L., Langlais, C., Jukes-Jones, R., de Moor, C. H., ... & Bushell, M. (2019). DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity. Nucleic Acids Research, 47(15), 8224-8238.

Ndzinu, J. K., Takeuchi, H., Saito, H., Yoshida, T., & Yamaoka, S. (2018). eIF4A2 is a host factor required for efficient HIV-1 replication. Microbes and Infection, 20(6), 346-352.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-EIF4A2 Monoclonal Antibody (2B5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry