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Mouse Anti-EIF4A2 Antibody (2B5) (CBMAB-0339-YC)

Provided herein are mouse monoclonal antibodies against Human EIF4A2. The antibody clone 2B5
can be used for immunoassay techniques, such as IP and MA.
See all EIF4A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2B5
Antibody Isotype
IgG2c
Application
IP, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Eukaryotic Translation Initiation Factor 4A2
Introduction
EIF4A2 (eukaryotic translation initiation factor 4A2) a protein that in humans is encoded by the EIF4A2 gene. EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2 diabetes in French families, which controls specific mRNA translation and protein synthesis rate in pancreatic β-cells.
Entrez Gene ID
9775
UniProt ID
P38919
Alternative Names
DDX48; EIF4AIII
Research Area
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Biological Process
Cellular response to leukemia inhibitory factor Source: Ensembl
Cytoplasmic translational initiation Source: GO_Central
Negative regulation of RNA-directed 5'-3' RNA polymerase activity Source: AgBase
Regulation of translational initiation Source: ProtInc
Cellular Location
Cytosol; Eukaryotic translation initiation factor 4F complex; Perinuclear region of cytoplasm

Li, D., Yang, J., Huang, X., Zhou, H., & Wang, J. (2022). eIF4A2 targets developmental potency and histone H3. 3 transcripts for translational control of stem cell pluripotency. Science advances, 8(13), eabm0478.

Zhang, Z., Peng, M., Wen, Y., Chai, Y., Liang, J., Yang, P., ... & Huang, Y. (2022). Copy number variation of EIF4A2 loci related to phenotypic traits in Chinese cattle. Veterinary Medicine and Science.

Alwaqfi, R. R., Davick, J. J., & Bossler, A. D. (2022). EIF4A2 as another novel fusion partner of PLAG1 in lipoblastoma. Human Pathology Reports, 27, 300582.

Bolland, H. (2020). eIF4A2 is a regulator of hypoxic translation and colorectal tumour cell survival (Doctoral dissertation, University of Nottingham).

Lyu, S., Lu, J., Chen, W., Huang, W., Huang, H., Xi, S., & Yan, S. (2020). High expression of eIF4A2 is associated with a poor prognosis in esophageal squamous cell carcinoma. Oncology Letters, 20(5), 1-1.

Song, Z., Yang, Y., Wang, L., Wang, K., Ran, L., Xie, Y., ... & Yu, Q. (2019). EIF4A2 interacts with the membrane protein of transmissible gastroenteritis coronavirus and plays a role in virus replication. Research in veterinary science, 123, 39-46.

Wilczynska, A., Gillen, S. L., Schmidt, T., Meijer, H. A., Jukes-Jones, R., Langlais, C., ... & Bushell, M. (2019). eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5′ UTR. Genome biology, 20(1), 1-21.

Liu, M., Gong, C., Xu, R., Chen, Y., & Wang, X. (2019). MicroRNA-5195-3p enhances the chemosensitivity of triple-negative breast cancer to paclitaxel by downregulating EIF4A2. Cellular & Molecular Biology Letters, 24(1), 1-11.

Meijer, H. A., Schmidt, T., Gillen, S. L., Langlais, C., Jukes-Jones, R., de Moor, C. H., ... & Bushell, M. (2019). DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity. Nucleic Acids Research, 47(15), 8224-8238.

Ndzinu, J. K., Takeuchi, H., Saito, H., Yoshida, T., & Yamaoka, S. (2018). eIF4A2 is a host factor required for efficient HIV-1 replication. Microbes and Infection, 20(6), 346-352.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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