GAD2
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
Full Name
Glutamate Decarboxylase 2
Function
Catalyzes the production of GABA.
Biological Process
Chemical synaptic transmission Source: ProtInc
Glutamate decarboxylation to succinate Source: ProtInc
Neurotransmitter biosynthetic process Source: UniProtKB-KW
Response to drug Source: Ensembl
Glutamate decarboxylation to succinate Source: ProtInc
Neurotransmitter biosynthetic process Source: UniProtKB-KW
Response to drug Source: Ensembl
Cellular Location
Cytosol; Presynaptic cell membrane; Golgi apparatus membrane; Cytoplasmic vesicle. Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
PTM
Phosphorylated; which does not affect kinetic parameters or subcellular location.
Palmitoylated; which is required for presynaptic clustering.
Palmitoylated; which is required for presynaptic clustering.
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Anti-GAD2 antibodies
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CompareTarget: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: CBLG1-487
Application*: WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rat
Clone: CBLG1-483
Application*: P, IP, R, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rat
Clone: N-GAD65
Application*: IP, R, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CL2736
Application*: WB, IH
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D9G12
Application*: WB, E, F
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5D9G9
Application*: E, F, IH, IC, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G3
Application*: E, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4198
Application*: WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4044
Application*: F
Target: GAD2
Specificity: Human
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP806
Application*: ICC, IHC, IP, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0703
Application*: SE
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0702
Application*: SE
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0661
Application*: SE
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0660
Application*: SE
Target: GAD2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: 6D5-E8-E4
Application*: WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-489
Application*: SE, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-488
Application*: IC, C/P, E (IA), WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-484
Application*: WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-481
Application*: E, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-480
Application*: IH, IP, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-478
Application*: E
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBLG1-476
Application*: E, IP, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-475
Application*: WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG3
Specificity: Rat, Mouse
Clone: CBLG1-474
Application*: IC, IP, E, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: ZG002
Application*: E, P, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: TS106
Application*: E, WB
Target: GAD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-2525
Application*: WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 9A6
Application*: IH, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 83/2E6
Application*: IC, IH, IP, R
Target: GAD2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: 6-1
Application*: WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2736
Application*: WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 144
Application*: F
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: 13j39
Application*: E, IC, IH, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 114-4E8
Application*: WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-023
Application*: E, WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 458CT17.2.4
Application*: WB
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2963
Application*: E, WB
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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