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GAD2

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]
Full Name
Glutamate Decarboxylase 2
Function
Catalyzes the production of GABA.
Biological Process
Chemical synaptic transmission Source: ProtInc
Glutamate decarboxylation to succinate Source: ProtInc
Neurotransmitter biosynthetic process Source: UniProtKB-KW
Response to drug Source: Ensembl
Cellular Location
Cytosol; Presynaptic cell membrane; Golgi apparatus membrane; Cytoplasmic vesicle. Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.
PTM
Phosphorylated; which does not affect kinetic parameters or subcellular location.
Palmitoylated; which is required for presynaptic clustering.

Anti-GAD2 antibodies

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Mouse Anti-GAD2 Monoclonal Antibody (CBFYH-2963) (CBMAB-H1091-FY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2963
Application*: E, WB

Mouse Anti-GAD2 Recombinant Antibody (CL2736) (CBMAB-1555-CN)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CL2736
Application*: WB, IH

Mouse Anti-GAD2 Recombinant Antibody (5D9G12) (CBMAB-1554-CN)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D9G12
Application*: WB, E, F

Mouse Anti-GAD2 Monoclonal Antibody (5D9G9) (CBMAB-1316-YC)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 5D9G9
Application*: E, F, IH, IC, WB

Mouse Anti-GAD2 Monoclonal Antibody (3G3) (CBMAB-1315-YC)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G3
Application*: E, WB

Mouse Anti-GAD2 Recombinant Antibody (CAP806) (CBMAB-AP2450LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CAP806
Application*: ICC, IHC, IP, WB

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-484) (CBMAB-G1757-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-484
Application*: WB

Mouse Anti-GAD2 Monoclonal Antibody (CBFYR0703) (CBMAB-R0703-FY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0703
Application*: SE

Mouse Anti-GAD2 Monoclonal Antibody (CBFYR0702) (CBMAB-R0702-FY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0702
Application*: SE

Mouse Anti-GAD2 Monoclonal Antibody (CBFYR0661) (CBMAB-R0661-FY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0661
Application*: SE

Mouse Anti-GAD2 Monoclonal Antibody (CBFYR0660) (CBMAB-R0660-FY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0660
Application*: SE

Mouse Anti-GAD2 Recombinant Antibody (458CT17.2.4) (CBMAB-G0141-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 458CT17.2.4
Application*: WB

Mouse Anti-GAD2 Recombinant Antibody (N-GAD65) (CBMAB-G0145-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rat
Clone: N-GAD65
Application*: IP, R, WB

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-023) (CBMAB-G0146-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-023
Application*: E, WB

Mouse Anti-GAD2 Recombinant Antibody (114-4E8) (CBMAB-G1730-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 114-4E8
Application*: WB

Mouse Anti-GAD2 Recombinant Antibody (13j39) (CBMAB-G1731-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: 13j39
Application*: E, IC, IH, WB

Mouse Anti-GAD2 Recombinant Antibody (144) (CBMAB-G1732-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 144
Application*: F

Mouse Anti-GAD2 Recombinant Antibody (2736) (CBMAB-G1733-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2736
Application*: WB

Mouse Anti-GAD2 Recombinant Antibody (6-1) (CBMAB-G1737-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Rat
Clone: 6-1
Application*: WB

Mouse Anti-GAD2 Recombinant Antibody (83/2E6) (CBMAB-G1738-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 83/2E6
Application*: IC, IH, IP, R

Mouse Anti-GAD2 Recombinant Antibody (9A6) (CBMAB-G1739-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 9A6
Application*: IH, WB

Rabbit Anti-GAD2 Recombinant Antibody (CBLG1-2525) (CBMAB-G1744-LY)

Datasheet SDS
Target: GAD2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBLG1-2525
Application*: WB

Mouse Anti-GAD2 Recombinant Antibody (TS106) (CBMAB-G1745-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: TS106
Application*: E, WB

Mouse Anti-GAD2 Recombinant Antibody (ZG002) (CBMAB-G1746-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: ZG002
Application*: E, P, WB

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-474) (CBMAB-G1747-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG3
Specificity: Rat, Mouse
Clone: CBLG1-474
Application*: IC, IP, E, WB

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-475) (CBMAB-G1748-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-475
Application*: WB

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-476) (CBMAB-G1749-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBLG1-476
Application*: E, IP, WB

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-478) (CBMAB-G1751-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-478
Application*: E

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-480) (CBMAB-G1753-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-480
Application*: IH, IP, WB

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-481) (CBMAB-G1754-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-481
Application*: E, WB

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-483) (CBMAB-G1756-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rat
Clone: CBLG1-483
Application*: P, IP, R, WB

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-487) (CBMAB-G1760-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: CBLG1-487
Application*: WB

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-488) (CBMAB-G1761-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBLG1-488
Application*: IC, C/P, E (IA), WB

Mouse Anti-GAD2 Recombinant Antibody (CBLG1-489) (CBMAB-G1762-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBLG1-489
Application*: SE, WB

Mouse Anti-GAD2 Recombinant Antibody (6D5-E8-E4) (CBMAB-Z0221-LY)

Datasheet SDS
Target: GAD2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: 6D5-E8-E4
Application*: WB

GAD2 Matched Antibody Pair (460) (APMAB-460LY)

Datasheet SDS
Target: GAD2
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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