Mouse Anti-GAD2 Recombinant Antibody (CBLG1-480) (CBMAB-G1753-LY)

Name: Mouse Anti-GAD2 Recombinant Antibody (CBLG1-480)
SKU: CBMAB-G1753-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBLG1-480

Application

IHC, IP, WB

Immunogen

Synthetic peptide corresponding to aa4-22, PGSGFWSFGSEDGSGDSEN from within the N-terminal region of human GAD65 conjugated at KLH. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan (100%), Gibbon, Galago, Rat, Ferret, Panda, Bovine, Feline, Canine, Equine, Porcine (95%),Monkey, Marmoset, Mouse, Rabbit, Opossum, Guinea Porcine (89%)

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Glutamate Decarboxylase 2

Introduction

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008]

Entrez Gene ID

2572

UniProt ID

Q05329

Alternative Names

Glutamate Decarboxylase 2; Glutamate Decarboxylase 2 (Pancreatic Islets And Brain; 65kDa); Glutamate Decarboxylase 65 KDa Isoform; 5 KDa Glutamic Acid Decarboxylase; EC 4.1.1.15; GAD-65;

Function

Catalyzes the production of GABA.

Biological Process

Chemical synaptic transmission Source: ProtInc
Glutamate decarboxylation to succinate Source: ProtInc
Neurotransmitter biosynthetic process Source: UniProtKB-KW
Response to drug Source: Ensembl

Cellular Location

Cytosol; Presynaptic cell membrane; Golgi apparatus membrane; Cytoplasmic vesicle. Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters.

PTM

Phosphorylated; which does not affect kinetic parameters or subcellular location.
Palmitoylated; which is required for presynaptic clustering.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

GAD2 Matched Antibody Pair (460) (CAT#: APMAB-460LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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