GOT1

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq]

Glutamic-Oxaloacetic Transaminase 1

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.

2-oxoglutarate metabolic process Source: UniProtKB
Aspartate biosynthetic process Source: GO_Central
Aspartate catabolic process Source: UniProtKB
Aspartate metabolic process Source: UniProtKB
Cellular response to insulin stimulus Source: UniProtKB
Cellular response to mechanical stimulus Source: Ensembl
Fatty acid homeostasis Source: Ensembl
Glutamate catabolic process to 2-oxoglutarate Source: Ensembl
Glutamate catabolic process to aspartate Source: Ensembl
Glutamate metabolic process Source: UniProtKB
Glycerol biosynthetic process Source: UniProtKB
Negative regulation of collagen biosynthetic process Source: Ensembl
Negative regulation of cytosolic calcium ion concentration Source: Ensembl
Negative regulation of mitochondrial depolarization Source: Ensembl
Notch signaling pathway Source: Ensembl
Oxaloacetate metabolic process Source: Ensembl
Positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to carbohydrate Source: Ensembl
Response to glucocorticoid Source: UniProtKB
Response to immobilization stress Source: Ensembl
Response to transition metal nanoparticle Source: Ensembl
Transdifferentiation Source: Ensembl

Cytoplasm