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Mouse Anti-GOT1 Recombinant Antibody (4G4) (CBMAB-G4405-LY)

This product is antibody recognizes GOT1. The antibody 4G4 immunoassay techniques such as: ELISA.
See all GOT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G4
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
GOT1 (NP_002070.1, 1 a.a. ~ 413 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MAPPSVFAEV PQAQPVLVFK LTADFREDPD PRKVNLGVGA YRTDDCHPWV LPVVKKVEQK IANDNSLNHE YLPILGLAEF RSCASRLALG DDSPALKEKR VGGVQSLGGT GALRIGADFL ARWYNGTNNK NTPVYVSSPT WENHNAVFSA AGFKDIRSYR YWDAEKRGLD LQGFLNDLEN APEFSIVVLH ACAHNPTGID PTPEQWKQIA SVMKHRFLFP FFDSAYQGFA SGNLERDAWA IRYFVSEGFE FFCAQSFSKN FGLYNERVGN LTVVGKEPES ILQVLSQMEK IVRITWSNPP AQGARIVAST LSNPELFEEW TGNVKTMADR ILTMRSELRA RLEALKTPGT WNHITDQIGM FSFTGLNPKQ VEYLVNEKHI YLLPSGRINV SGLTTKNLDY VATSIHEAVT KIQ
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glutamic-Oxaloacetic Transaminase 1
Entrez Gene ID
2805
UniProt ID
P17174
Alternative Names
Glutamic-Oxaloacetic Transaminase 1; Glutamate Oxaloacetate Transaminase 1; Glutamic-Oxaloacetic Transaminase 1; Soluble; Cysteine Aminotransferase; Cytoplasmic; Cysteine Transaminase; Cytoplasmic; Aspartate Aminotransferase 1; Aspartate Transaminase 1; Transaminase A; EC 2.6.1.1; CAspAT;
Function
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Biological Process
2-oxoglutarate metabolic process Source: UniProtKB
Aspartate biosynthetic process Source: GO_Central
Aspartate catabolic process Source: UniProtKB
Aspartate metabolic process Source: UniProtKB
Cellular response to insulin stimulus Source: UniProtKB
Cellular response to mechanical stimulus Source: Ensembl
Fatty acid homeostasis Source: Ensembl
Glutamate catabolic process to 2-oxoglutarate Source: Ensembl
Glutamate catabolic process to aspartate Source: Ensembl
Glutamate metabolic process Source: UniProtKB
Glycerol biosynthetic process Source: UniProtKB
Negative regulation of collagen biosynthetic process Source: Ensembl
Negative regulation of cytosolic calcium ion concentration Source: Ensembl
Negative regulation of mitochondrial depolarization Source: Ensembl
Notch signaling pathway Source: Ensembl
Oxaloacetate metabolic process Source: Ensembl
Positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to carbohydrate Source: Ensembl
Response to glucocorticoid Source: UniProtKB
Response to immobilization stress Source: Ensembl
Response to transition metal nanoparticle Source: Ensembl
Transdifferentiation Source: Ensembl
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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