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Mouse Anti-GOT1 Recombinant Antibody (CBWJC-3731) (CBMAB-C4996WJ)

This product is a Mouse antibody that recognizes GOT1. This antibody CBWJC-3731 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-F, ELISA, IP, IF, FC.
See all GOT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-3731
Antibody Isotype
IgG2a, κ
Application
WB, ICC, IHC-P, IHC-F, ELISA, IP, IF, FC

Basic Information

Immunogen
Aspartate Aminotransferase
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glutamic-Oxaloacetic Transaminase 1
Introduction
GOT1 (Glutamic-Oxaloacetic Transaminase 1) is a Protein Coding gene. Diseases associated with GOT1 include Aspartate Aminotransferase, Serum Level Of, Quantitative Trait Locus 1 and Cholesterol Ester Storage Disease. Among its related pathways are superpathway of methionine degradation and Metabolism. Gene Ontology (GO) annotations related to this gene include pyridoxal phosphate binding and carboxylic acid binding. An important paralog of this gene is GOT2.
Entrez Gene ID
2805
UniProt ID
P17174
Alternative Names
Glutamic-Oxaloacetic Transaminase 1; Glutamate Oxaloacetate Transaminase 1; Glutamic-Oxaloacetic Transaminase 1, Soluble; Cysteine Aminotransferase, Cytoplasmic; Cysteine Transaminase, Cytoplasmic; Aspartate Aminotransferase 1; Aspartate Transaminase 1; Transaminase A; EC 2.6.1.1; CAspAT;
Function
Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H2S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
Biological Process
2-oxoglutarate metabolic process Source: UniProtKB
Aspartate biosynthetic process Source: GO_Central
Aspartate catabolic process Source: UniProtKB
Aspartate metabolic process Source: UniProtKB
Cellular response to insulin stimulus Source: UniProtKB
Cellular response to mechanical stimulus Source: Ensembl
Fatty acid homeostasis Source: Ensembl
Glutamate catabolic process to 2-oxoglutarate Source: Ensembl
Glutamate catabolic process to aspartate Source: Ensembl
Glutamate metabolic process Source: UniProtKB
Glycerol biosynthetic process Source: UniProtKB
Negative regulation of collagen biosynthetic process Source: Ensembl
Negative regulation of cytosolic calcium ion concentration Source: Ensembl
Negative regulation of mitochondrial depolarization Source: Ensembl
Notch signaling pathway Source: Ensembl
Oxaloacetate metabolic process Source: Ensembl
Positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
Response to cadmium ion Source: Ensembl
Response to carbohydrate Source: Ensembl
Response to glucocorticoid Source: UniProtKB
Response to immobilization stress Source: Ensembl
Response to transition metal nanoparticle Source: Ensembl
Transdifferentiation Source: Ensembl
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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