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IL15

The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
Full Name
Interleukin 15
Function
Cytokine that stimulates the proliferation of T-lymphocytes (PubMed:8178155).

Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (PubMed:8178155).

In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (PubMed:15123770).
Biological Process
Aging Source: Ensembl
Cell-cell signaling Source: ProtInc
Cell maturation Source: Ensembl
Cellular response to vitamin D Source: Ensembl
Extrathymic T cell selection Source: Ensembl
Hyaluronan metabolic process Source: Ensembl
Immune response Source: ProtInc
Inflammatory response Source: Ensembl
Interleukin-15-mediated signaling pathway Source: UniProtKB
Lymph node development Source: Ensembl
Macrophage differentiation Source: ARUK-UCL
Negative regulation of cold-induced thermogenesis Source: YuBioLab
Negative regulation of smooth muscle cell proliferation Source: Ensembl
Neutrophil activation Source: UniProtKB
NK T cell proliferation Source: Ensembl
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of cytokine production Source: GO_Central
Positive regulation of immune response Source: GO_Central
Positive regulation of inflammatory response Source: BHF-UCL
Positive regulation of interleukin-17 production Source: BHF-UCL
Positive regulation of natural killer cell differentiation Source: Ensembl
Positive regulation of natural killer cell proliferation Source: Ensembl
Positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
Positive regulation of phagocytosis Source: UniProtKB
Positive regulation of protein O-linked glycosylation Source: Ensembl
Positive regulation of T cell proliferation Source: GO_Central
Positive regulation of tissue remodeling Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: GO_Central
Regulation of defense response to virus by host Source: Ensembl
Regulation of T cell differentiation Source: Ensembl
Signal transduction Source: ProtInc
Skeletal muscle atrophy Source: Ensembl
Tyrosine phosphorylation of STAT protein Source: CACAO
Cellular Location
Isoform IL15-S48AA: Secreted
Isoform IL15-S21AA: Nucleus; Cytoplasm. IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.

Anti-IL15 antibodies

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Target: IL15
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I2038
Application*: WB
Target: IL15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1962
Application*: WB
Target: IL15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1444
Application*: E, IH, IP, WB
Target: IL15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1024
Application*: E
Target: IL15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0957
Application*: E, WB
Target: IL15
Host: Human
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0858
Application*: ED
Target: IL15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B-E29
Application*: F, E, FN, BL, N
Target: IL15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BDI150
Application*: E, IH, IP, WB
Target: IL15
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: AIO.3
Application*: P, N, FN
Target: IL15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0545
Application*: FN, N
Target: IL15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0496
Application*: E, IH, P
Target: IL15
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I0138
Application*: WB, E
Target: IL15
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: A471
Application*: ICC, IHC, IP, WB
Target: IL15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A470
Application*: Sandwich ELISA, Western Blot
Target: IL15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0259
Application*: SE
Target: IL15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0258
Application*: SE
Target: IL15
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C6
Application*: WB, E
Target: IL15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B9
Application*: WB, E
Target: IL15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3A4
Application*: IF, E
Target: IL15
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3A3
Application*: WB, E
Target: IL15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H7
Application*: IF, E
Target: IL15
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2G3
Application*: E, E
Target: IL15
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2F6
Application*: E, E
Target: IL15
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G3
Application*: IF, E
Target: IL15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3E8
Application*: WB, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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