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IL15 Matched Antibody Pair (618) (APMAB-618LY)

This antibody pair set can be used for detecting and quantifying protein level of human IL15.
See all IL15 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-IL15 polyclonal antibody, 100 ug
Detection Antibody
Anti-IL15 Mouse polyclonal antibody, 40 ul
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
Alternative Names
Interleukin 15
Entrez Gene ID
3600
UniProt ID
P40933

Aryee, K. E., Burzenski, L. M., Yao, L. C., Keck, J. G., Greiner, D. L., Shultz, L. D., & Brehm, M. A. (2022). Enhanced development of functional human NK cells in NOD‐scid‐IL2rgnull mice expressing human IL15. The FASEB Journal, 36(9).

Ma, R., Lu, T., Li, Z., Teng, K. Y., Mansour, A. G., Yu, M., ... & Yu, J. (2021). An oncolytic virus expressing IL15/IL15Rα combined with off-the-shelf EGFR-CAR NK cells targets glioblastoma. Cancer research, 81(13), 3635-3648.

Batra, S. A., Rathi, P., Guo, L., Courtney, A. N., Fleurence, J., Balzeau, J., ... & Heczey, A. (2020). Glypican-3–specific CAR T cells coexpressing IL15 and IL21 have superior expansion and antitumor activity against hepatocellular carcinoma. Cancer immunology research, 8(3), 309-320.

Chauvin, J. M., Ka, M., Pagliano, O., Menna, C., Ding, Q., DeBlasio, R., ... & Zarour, H. M. (2020). IL15 stimulation with TIGIT blockade reverses CD155-mediated NK-cell dysfunction in melanoma. Clinical Cancer Research, 26(20), 5520-5533.

Alizadeh, D., Wong, R. A., Yang, X., Wang, D., Pecoraro, J. R., Kuo, C. F., ... & Brown, C. E. (2019). IL15 enhances CAR-T cell antitumor activity by reducing mTORC1 activity and preserving their stem cell memory phenotype. Cancer immunology research, 7(5), 759-772.

Xu, X., Huang, W., Heczey, A., Liu, D., Guo, L., Wood, M., ... & Metelitsa, L. S. (2019). NKT cells coexpressing a GD2-specific chimeric antigen receptor and IL15 show enhanced in vivo persistence and antitumor activity against neuroblastoma. Clinical Cancer Research, 25(23), 7126-7138.

Conlon, K. C., Potter, E. L., Pittaluga, S., Lee, C. C. R., Miljkovic, M. D., Fleisher, T. A., ... & Waldmann, T. A. (2019). IL15 by continuous intravenous infusion to adult patients with solid tumors in a phase I trial induced dramatic NK-cell subset expansion. Clinical Cancer Research, 25(16), 4945-4954.

Margolin, K., Morishima, C., Velcheti, V., Miller, J. S., Lee, S. M., Silk, A. W., ... & Ernstoff, M. S. (2018). Phase I trial of ALT-803, a novel recombinant IL15 complex, in patients with advanced solid tumors. Clinical Cancer Research, 24(22), 5552-5561.

Miller, J. S., Morishima, C., McNeel, D. G., Patel, M. R., Kohrt, H. E., Thompson, J. A., ... & Conlon, K. C. (2018). A first-in-human phase I study of subcutaneous outpatient recombinant human IL15 (rhIL15) in adults with advanced solid tumors. Clinical Cancer Research, 24(7), 1525-1535.

Borrelli, C., Ricci, B., Vulpis, E., Fionda, C., Ricciardi, M. R., Petrucci, M. T., ... & Soriani, A. (2018). Drug-induced senescent multiple myeloma cells elicit NK cell proliferation by direct or exosome-mediated IL15 trans-presentation. Cancer immunology research, 6(7), 860-869.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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