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KERA

The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010]

Full Name

Keratocan

Function

May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.

Biological Process

Cornea development in camera-type eyeIEA:Ensembl
Response to stimulusIEA:UniProtKB-KW
Visual perceptionIEA:UniProtKB-KW

Cellular Location

Secreted, extracellular space, extracellular matrix

Involvement in disease

Cornea plana 2, autosomal recessive (CNA2):
A severe form of cornea plana, a rare ocular disorder characterized by flattened corneal curvature leading to a decrease in refraction, reduced visual activity, hyperopia, hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis often detected at an early age. CNA2 patients manifest extreme hyperopia and additional ocular anomalies such as malformations of the iris, a slit-like pupil, and adhesions between iris and cornea.

PTM

Binds keratan sulfate chains.

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Anti-KERA antibodies

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Mouse Anti-KERA Recombinant Antibody (Ker-1) (CBMAB-K0780-LY)

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Target: KERA

Host: Mouse

Antibody Isotype: IgM

Specificity: Human, Cattle, Pig, Mouse, Chicken

Clone: Ker-1

Application*: WB, IH, IA

Mouse Anti-KERA Recombinant Antibody (13A204) (CBMAB-K0779-LY)

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Target: KERA

Host: Mouse

Antibody Isotype: IgM

Specificity: Cattle

Clone: 13A204

Application*: IH, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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