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Mouse Anti-KERA Recombinant Antibody (Ker-1) (CBMAB-K0780-LY)

This product is antibody recognizes KERA. The antibody Ker-1 immunoassay techniques such as: WB, IHC, EIA.
See all KERA antibodies

Summary

Host Animal
Mouse
Specificity
Human, Cattle, Pig, Mouse, Chicken
Clone
Ker-1
Antibody Isotype
IgM
Application
WB, IHC, EIA

Basic Information

Immunogen
This Keratocan antibody recognises a protein core epitope in human, bovine, porcine, mouse & chicken tissues
Specificity
Human, Cattle, Pig, Mouse, Chicken
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Keratocan
Introduction
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010]
Entrez Gene ID
Human11081
Mouse16545
Chicken373995
Cattle280785
Pig100157843
UniProt ID
HumanO60938
MouseO35367
ChickenO42235
CattleO62702
PigF1SQ08
Function
May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.
Biological Process
Cornea development in camera-type eyeIEA:Ensembl
Response to stimulusIEA:UniProtKB-KW
Visual perceptionIEA:UniProtKB-KW
Cellular Location
Secreted, extracellular space, extracellular matrix
Involvement in disease
Cornea plana 2, autosomal recessive (CNA2):
A severe form of cornea plana, a rare ocular disorder characterized by flattened corneal curvature leading to a decrease in refraction, reduced visual activity, hyperopia, hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis often detected at an early age. CNA2 patients manifest extreme hyperopia and additional ocular anomalies such as malformations of the iris, a slit-like pupil, and adhesions between iris and cornea.
PTM
Binds keratan sulfate chains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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